Mechanism of the cytotoxic effect of noble metal polyacrylates on tumor cells

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Abstract

The present study was carried out to investigate and compare the cytotoxic activities and mechanism of action of gold polyacrylates (aurumacryl) and silver polyacrylates (argacryl) using human tumor cell line (MCF-7 cell culture). The tested compounds showed high cytotoxic activity. It was found that argacryl is 20 times more effective than aurumacryl. It was established that apoptosis represents the dominant mechanism by which tumor cells undergo cell death induced by aurumacryl and argacryl. Differences in the effect of drugs on the DNA structure in tumor cells were found.

About the authors

A. K Chigasova

Emanuel Institute of Biochemical Physics, Russian Academy of Sciences

Moscow, Russia

L. A Ostrovskaya

Emanuel Institute of Biochemical Physics, Russian Academy of Sciences

Email: larros@list.ru
Moscow, Russia

D. B Korman

Emanuel Institute of Biochemical Physics, Russian Academy of Sciences

Moscow, Russia

N. V Bluhterova

Emanuel Institute of Biochemical Physics, Russian Academy of Sciences

Moscow, Russia

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