Nanodiamonds as lutetium-177 carriers for nuclear medicine

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Abstract

The work investigated the sorption of carrier-free 177Lu isolated from neutron-irradiated 176Yb2O3, and with a carrier obtained by irradiation of natLu2O3, by commercial and oxidized nanodiamonds (NDs) of various brands from aqueous solutions to identify among them a promising carrier for further research for the purposes of nuclear medicine. A promising sorbent was found: oxidized NDs of the STP brand (ox-STP); conditions for the rapid sorption of lutetium by it in an amount equivalent to 1.2 GBq of carrier-free 177Lu were determined, which corresponds to the activity used in therapy.

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About the authors

A. G. Kazakov

Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences

Author for correspondence.
Email: adeptak92@mail.ru
Russian Federation, Moscow

J. S. Babenya

Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences

Email: adeptak92@mail.ru
Russian Federation, Moscow

T. Y. Ekatova

Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences

Email: adeptak92@mail.ru
Russian Federation, Moscow

S. E. Vinokurov

Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences

Email: adeptak92@mail.ru
Russian Federation, Moscow

E. Y. Khvorostinin

Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences

Email: adeptak92@mail.ru
Russian Federation, Moscow

I. A. Ushakov

National Research Tomsk Polytechnic University

Email: adeptak92@mail.ru
Russian Federation, Tomsk

V. V. Zukau

National Research Tomsk Polytechnic University

Email: adeptak92@mail.ru
Russian Federation, Tomsk

E. S. Stasyuk

National Research Tomsk Polytechnic University

Email: adeptak92@mail.ru
Russian Federation, Tomsk

E. A. Nesterov

National Research Tomsk Polytechnic University

Email: adeptak92@mail.ru
Russian Federation, Tomsk

V. L. Sadkin

National Research Tomsk Polytechnic University

Email: adeptak92@mail.ru
Russian Federation, Tomsk

A. S. Rogov

National Research Tomsk Polytechnic University

Email: adeptak92@mail.ru
Russian Federation, Tomsk

B. F. Myasoedov

Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences; Interdepartmental Center for Analytical Research in Physics, Chemistry and Biology, Russian Academy of Sciences

Email: adeptak92@mail.ru
Russian Federation, Moscow; Moscow

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Supplementary files

Supplementary Files
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2. Fig. 1. Elution curve of 177Lu-bn without carrier and Yb with α-HIBA solution on a Dowex 50WX8 column.

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3. Fig. 2. Sorption of 177Lu-bn by TAN (a) and ok-TAN (b) samples, 100 μg/ml

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4. Fig. 3. Sorption of 177Lu-bn TAN and ox-TAN at pH 5.6 for 5 min depending on the m/V ratio.

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5. Fig. 4. Sorption of 177Lu-sn (20 ng) by TAN sample, 100 μg/ml.

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6. Fig. 5. Sorption of 177Lu-sn (20 ng) by STP (a) and ox-STP (b) samples, 100 μg/ml.

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7. Fig. 6. Sorption of 177Lu-sn (20 ng) by STP and ox-STP samples at pH 5.6 for 30 min depending on the m/V ratio.

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8. Fig. 7. Sorption of 177Lu-sn (300 ng) by ox-STP at pH 5.6 depending on the m/V ratio.

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