Automated synthesis module for L-[11С-methyl]methionine: design, performance, and e ciency in PET

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Abstract

An automated module for the synthesis of L-[11C-methyl]methionine, a well-known PET radiotracer for brain tumor imaging, has been designed. The module meets modern requirements for the production of radiopharmaceuticals and radiation safety; thanks to the original program created in the Delphi programming environment, module is convenient for the synthesis control (user-friendly) and operation; the service can be maintained on its own with minimal time and nancial costs. The module ensures the production of L-[11C-methyl]methionine with high chemical, radiochemical and enantiomeric purity and a radiochemical yield of 30% (based on [11C]CO2 activity, not decay corrected).

About the authors

O. F. Kuznetsova

Bechtereva Institute of the Human Brain, Russian Academy of Sciences

V. V. Orlovskaya

Bechtereva Institute of the Human Brain, Russian Academy of Sciences

D. D. Vaulina

Bechtereva Institute of the Human Brain, Russian Academy of Sciences

V. Yu. Obolentsev

Bechtereva Institute of the Human Brain, Russian Academy of Sciences

A. S. Demyanov

Bechtereva Institute of the Human Brain, Russian Academy of Sciences

R. N. Krasikova

Bechtereva Institute of the Human Brain, Russian Academy of Sciences

Email: raisa@ihb.spb.ru

References

  1. Albert N.L., Weller M., Suchorska B., Galldiks N., Soffietti R., Kim M.M., la Fougère C., Pope W., Law I., Arbizu J., Chamberlain M.C., Vogelbaum M., Ellingson B.M., Tonn J.C. // Neuro Oncol. 2016. Vol. 18, N 9. P. 1199-1208.
  2. Скворцова Т.Ю., Бродская З.Л., Савинцева Ж.И., Гурчин А.Ф. // Лучевая диагностика и терапия. 2014. Т. 5, № 2. С. 5-16.
  3. Скворцова Т.Ю., Савинцева Ж.И., Захс Д.В., Тюрин Р.В., Гурчин А.Ф., Холявин А.И., Трофимова Т.Н. // Лучевая диагностика и терапия. 2021. Т. 12, № 1. С. 49-58.
  4. Comar D., Cartron J.-C., Maziere M., Marazano C. // Eur. J. Nucl. Med. 1976. Vol. 1. P. 11-14.
  5. Larsen P., Ulin J., Dahlström K., Jensen M. // Appl. Radiat. Isot. 1997. Vol. 48. P. 153-157.
  6. Link J.M., Krohn K.A., Clark J.C. // Nucl. Med. Biol. 1997. Vol. 24. P. 93-97.
  7. Larsen P., Orbe M., Dahlstrøm, K., Ulin J. US Patent 6008421. December 28, 1999.
  8. Mock B. // Curr. Org. Chem. 2013. Vol. 2013, N 17. P. 2119-2126.
  9. Andersson J., Truong P., Halldin C. // Appl. Radiat. Isot. 2009. Vol. 67. P. 106-110.
  10. Boschi S., Lodi F., Cicoria G., Raul Ledesma J., Knopp R., Rizzello A., Di Pierro D., Trespidi S., Marengo M. // Appl. Radiat. Isot. 2009. Vol. 67, N 10. P. 1869-1873.
  11. Lee J. A // Bull. Kor. Chem. Soc. 2020. Vol. 41, N 8. P. 799-804.
  12. Jolly D., Hopewell R., Kovacevic M., Li Q.Y., Soucy J.P., Kostikov A. // Appl. Radiat. Isot. 2017. Vol. 121. P. 76-81.
  13. Корсаков М.В., Красикова Р.Н., Соловьев Д.В. // Радиохимия. 1994. Т. 36. С. 272-274.
  14. Гомзина Н.А., Кузнецова О.Ф. // Биоорг. химия. 2011. Т. 37, № 2. С. 216-222.
  15. Pascali C., Bogni A., Iwata R., Decise D., Crippa F., Bombardieri E. // J. Label. Compd. Radiopharm. 1999. Vol. 42. P. 715-724.

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