Tritium labeling vancomycin and studying its adsorption on nanodiamonds

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Resumo

Procedure of tritium labeling vancomycin using tritium thermal activation method has been developed. The influence of target mass on the specific and total radioactivity was revealed. [3H]vancomycin was used for studying its equilibrium adsorption on nanodiamonds as well as its number that tightly bonded with surface and didn’t remove with water. It was found that adsorption from aqueous solution results in tightly bonded vancomycin with nanodiamonds that didn’t removed with water. Application of 0.028 M phosphate buffer (pH 6.7 and 2.7) leads to the equilibrium adsorption growth as much as one and a half times, while vancomycin number in the adsorption complex with nanodiamonds after washing with water was significantly reduced. Such behavior of vancomycin is due to the presence of phosphate-ions that contribute to vancomycin adsorption, but are removed during washing with water. Molecular mechanics simulation allows us to suggest the formation of multiple hydrogen bonds for formation of a durable adsorption complex of vancomycin with nanodiamonds.

Sobre autores

T. Shen

Lomonosov Moscow State University

M. Chernysheva

Lomonosov Moscow State University

Email: chernyshevamg@my.msu.ru

G. Badun

Lomonosov Moscow State University

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