3-hydroxyquinazoline derivatives, analogues of erastin, induce ferroptosis in colorectal cancer cells
- 作者: Osipov V.N.1, Vartanyan A.A.1, Khochenkov D.A.1, Gusev D.V.1, Fateenkova O.V.2, Khachatryan D.S.3, Borisova L.M.1
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隶属关系:
- N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of Russia
- I.M. Sechenov First Moscow State Medical University of the Ministry of Health of Russia (Sechenov University)
- National Research Center “Kurchatov Institute”
- 期: 卷 50, 编号 5 (2024)
- 页面: 601-611
- 栏目: Articles
- URL: https://cardiosomatics.ru/0132-3423/article/view/670789
- DOI: https://doi.org/10.31857/S0132342324050033
- EDN: https://elibrary.ru/LRZRMB
- ID: 670789
如何引用文章
详细
In recent years, significant progress has been achieved in the treatment of patients with colon cancer, but in most cases treatment is accompanied by the development of drug resistance. Recently discovered iron-dependent cell death, ferroptosis, makes it a promissing therapeutic target to reduce the recurrence rates. In this study we have examined the effect of 3-hydoxyquinazoline derivatives on ferroptosis induction in two colon cancer cells HCT-116 and DLD-1. The ferroptotic cell death was identified by the level of lipid peroxidation. The level of lipid peroxidation in HCT-116 cells induced by some compounds approached the activity of the reference drug erastin. This scenario changed significantly when the ferroptosis induction was studied in DLD-1 cells. Two 3-hydroxyquinazoline derivatives induced levels of lipid peroxidation in DLD-1 cells that exceeded those of erastin. The preliminary results obtained suggest that three new compounds can be considered as an antitumor agent for the treatment of colon cancer, and also indicate the prospects of further searching for ferroptosis inducers among 3-hydroxyquinazoline derivatives.
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作者简介
V. Osipov
N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of Russia
编辑信件的主要联系方式.
Email: ovn65@yandex.ru
俄罗斯联邦, Kashirskoe shosse 24, Moscow, 115478
A. Vartanyan
N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of Russia
Email: ovn65@yandex.ru
俄罗斯联邦, Kashirskoe shosse 24, Moscow, 115478
D. Khochenkov
N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of Russia
Email: ovn65@yandex.ru
俄罗斯联邦, Kashirskoe shosse 24, Moscow, 115478
D. Gusev
N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of Russia
Email: ovn65@yandex.ru
俄罗斯联邦, Kashirskoe shosse 24, Moscow, 115478
O. Fateenkova
I.M. Sechenov First Moscow State Medical University of the Ministry of Health of Russia (Sechenov University)
Email: ovn65@yandex.ru
俄罗斯联邦, ul. Trubetskaya 8/2, Moscow, 119991
D. Khachatryan
National Research Center “Kurchatov Institute”
Email: ovn65@yandex.ru
俄罗斯联邦, pl. Akad. Kurchatova 1, Moscow, 123182
L. Borisova
N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of Russia
Email: ovn65@yandex.ru
俄罗斯联邦, Kashirskoe shosse 24, Moscow, 115478
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