电邮这篇文章 Synthesis and study of antibacterial and anti-mao activity of new pyrazoline and pyrimidine derivatives based on (e)-1-(4-amyloxyphenyl)-3-arylprop-2-en-1-ones
- 作者: Isakhanyan A.U.1, Hovasyan Z.A.1, Madoyan R.A.2, Sukiasyan A.G.2, Chailyan S.G.2, Grigoryan A.S.1, Gasparyan H.V.1, Harutyunyan A.A.1
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隶属关系:
- Scientific and Technological Center for Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
- Institute of Biochemistry named after G. Buniatyan of the National Academy of Sciences of the Republic of Armenia
- 期: 卷 51, 编号 1 (2025)
- 页面: 137-143
- 栏目: Articles
- URL: https://cardiosomatics.ru/0132-3423/article/view/683103
- DOI: https://doi.org/10.31857/S0132342325010126
- EDN: https://elibrary.ru/LYSDQL
- ID: 683103
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详细
Five chalcones from the pentyloxyacetophenone series with aromatic aldehydes have been synthesized. New pyrazoline and pyrimidine derivatives have been successfully synthesized on their basis The antimicrobial activity of 15 synthesized compounds was studied. Antimicrobial and antifungal activity was determined by the agar diffusion method. Studies have shown that out of 15 compounds, 9 exhibit high antifungal activity against pathogenic fungi of the genus Candida, and some compounds exhibit antagonistic activity against pathogenic strains of Escherichia coli and Staphylococcus aureus. Studies of anti-monoamine oxidase activity showed that two compounds showed moderate activity at a concentration of 1.0 mM, inhibiting the deamination of 5-oxytryptamine (serotonin) by 68 and 65%, respectively, and the remaining compounds showed weak anti-MAO activity.
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作者简介
A. Isakhanyan
Scientific and Technological Center for Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
编辑信件的主要联系方式.
Email: anush.isakhanyan.51@mail.ru
亚美尼亚, Azatutyana
Z. Hovasyan
Scientific and Technological Center for Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
Email: anush.isakhanyan.51@mail.ru
亚美尼亚, Yerevan
R. Madoyan
Institute of Biochemistry named after G. Buniatyan of the National Academy of Sciences of the Republic of Armenia
Email: anush.isakhanyan.51@mail.ru
亚美尼亚, Yerevan
A. Sukiasyan
Institute of Biochemistry named after G. Buniatyan of the National Academy of Sciences of the Republic of Armenia
Email: anush.isakhanyan.51@mail.ru
亚美尼亚, Yerevan
S. Chailyan
Institute of Biochemistry named after G. Buniatyan of the National Academy of Sciences of the Republic of Armenia
Email: anush.isakhanyan.51@mail.ru
俄罗斯联邦, Yerevan
A. Grigoryan
Scientific and Technological Center for Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
Email: anush.isakhanyan.51@mail.ru
亚美尼亚, Yerevan
H. Gasparyan
Scientific and Technological Center for Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
Email: anush.isakhanyan.51@mail.ru
俄罗斯联邦, Yerevan
A. Harutyunyan
Scientific and Technological Center for Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
Email: anush.isakhanyan.51@mail.ru
亚美尼亚, Yerevan
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