Cytotoxic Copper(II) Complexes Based on 2,2'-Bipyridine/1,10- Phenanthroline and 5-(4-Chlorophenyl)-1H-tetrazole: Synthesis and Structures

Мұқаба

Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Рұқсат ақылы немесе тек жазылушылар үшін

Аннотация

Five coordination compounds [Cu2(Bipy)2L4]·C2H5OH (Iа, Ib), [Cu2(Dmbipy)2L4] (II),
[Cu2(Phen)2L4]·H2O (IIIa), [Cu2(Dmphen)2L4] (IVa), and [Cu2(Phendione’)2L4]·2C2H5OH·2H2O (V) are
synthesized from 5-(4-chlorophenyl)-1H-tetrazole (HL), where Bipy is 2,2'-bipyridine, Dmbipy is 4,4'-
dimethyl-2,2'-bipyridine, Phen is 1,10-phenanthroline, Dmphen is 4,7-dimethyl-1,10-phenanthroline, and
Phendione’ is 6-ethoxy-6-hydroxy-1,10-phenanthrolin-5-one. The crystal structures of the complexes are
determined by X-ray diffraction (XRD) of single crystals (CIF files CCDC nos. 2225368 (Ia), 2225369 (Ib),
2225370 (II), 2225372 (IIIa), 2225373 (IVa), and 2225371 (V)). The compounds are binuclear due to the
bridging function of the tetrazolate anion, and the coordination number of copper is five in all synthesized
complexes. The cytotoxic activity of the complexes against the Hep2 and HepG2 cancer cell lines and noncancerous
human fibroblasts MRC-5 is studied. The complexes exhibit pronounced cytotoxic properties, and
compound V has the maximum selectivity index with respect to the cancer cells.

Авторлар туралы

Yu. Golubeva

Nikolaev Institute of Inorganic Chemistry, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia

Email: lisalider@ngs.ru
Россия, Новосибирск

K. Smirnova

Nikolaev Institute of Inorganic Chemistry, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia

Email: lisalider@ngs.ru
Россия, Новосибирск

L. Klyushova

Research Institute of Molecular Biology and Biophysics, Federal Research Center of Fundamental and Translational Medicine,
Novosibirsk, Russia

Email: lisalider@ngs.ru
Россия, Новосибирск

A. Berezin

Nikolaev Institute of Inorganic Chemistry, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia

Email: lisalider@ngs.ru
Россия, Новосибирск

E. Lider

Nikolaev Institute of Inorganic Chemistry, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia

Хат алмасуға жауапты Автор.
Email: lisalider@ngs.ru
Россия, Новосибирск

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© Ю.А. Голубева, К.С. Смирнова, Л.С. Клюшова, А.С. Березин, Е.В. Лидер, 2023