Мақаланы E-mail арқылы жіберу Comparative Evaluation of Effectiveness of Biocatalytic Synthesis and Antibacterial Activity of Known Antibiotics and “Chimeric” Cephalosporin Compounds
- Авторлар: Sklyarenko A.V.1, Groshkova I.А.1, Gorbunov N.A.1, Vasiliev A.V.1, Kamaev A.V.1, Yarotsky S.V.1
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Мекемелер:
- National Research Center “Kurchatov Institute”
- Шығарылым: Том 60, № 3 (2024)
- Беттер: 266-273
- Бөлім: Articles
- URL: https://cardiosomatics.ru/0555-1099/article/view/674553
- DOI: https://doi.org/10.31857/S0555109924030055
- EDN: https://elibrary.ru/EWWSTE
- ID: 674553
Дәйексөз келтіру
Ашық рұқсат
Рұқсат берілді
Аннотация
The processes of biocatalytic synthesis of cefamandole and cefazoline, as well as four “chimeric” cephalosporins carrying functional groups of these antibiotics in the C3 or C7 position of β-lactam, were carried out using immobilized cephalosporin-acid synthetase under mild standard conditions. A higher efficiency of biocatalytic acylation of β-lactams with a 1(H)-tetrazolylacetic acid residue compared to acylation with almond acid residue was demonstrated. The chemical structure of the obtained compounds was confirmed using the HPLC–MS method. The possibility of using directly reaction mixtures for evaluating the antibacterial activity of synthesized compounds without isolating the target products was demonstrated. The activity of the obtained cephalosporins against twelve microorganisms belonging to the genera Enterococcus, Acinetobacter, Serratia, Pseudomonas, Staphylococcus and Escherichia was evaluated by diffusion into agar. The activity of synthesized “chimeric” cephalosporins against four microorganisms was found: Escherichia coli VKPM B-6695, Staphylococcus aureus VKPM B-6646, Staphylococcus aureus VKPM B-8171 and Staphylococcus epidermidis VKPM B-12635.
Негізгі сөздер
Толық мәтін
Авторлар туралы
A. Sklyarenko
National Research Center “Kurchatov Institute”
Хат алмасуға жауапты Автор.
Email: ingagrosh@mail.ru
Ресей, Moscow
I. Groshkova
National Research Center “Kurchatov Institute”
Email: ingagrosh@mail.ru
Ресей, Moscow
N. Gorbunov
National Research Center “Kurchatov Institute”
Email: ingagrosh@mail.ru
Ресей, Moscow
A. Vasiliev
National Research Center “Kurchatov Institute”
Email: ingagrosh@mail.ru
Ресей, Moscow
A. Kamaev
National Research Center “Kurchatov Institute”
Email: ingagrosh@mail.ru
Ресей, Moscow
S. Yarotsky
National Research Center “Kurchatov Institute”
Email: ingagrosh@mail.ru
Ресей, Moscow
Әдебиет тізімі
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