Non-coding RNAs as biomarkers of Brugada syndrome (literature review)



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Abstract

Most of the causes of sudden cardiac death (SCD) are associated with cardiac arrhythmias, which often develop against the background of Brugada syndrome (BS). This pathology is associated with mutations in approximately 20 genes, but not all patients can be diagnosed with these disorders. Today, a major role is given to non-coding ribonucleic acids (RNA), which are involved in transcriptional, post-transcriptional and epigenetic regulation. The main non-coding RNAs found in BS include microRNAs. They are involved in pathogenesis, interacting with ion channels, and can also be used as biomarkers for timely diagnosis and prevention of life-threatening arrhythmias and fatal cases. Thus, the search for optimal biomarkers and determination of their role in the diagnosis of BS can become the basis for early detection and pathogenetically substantiated treatment of BS. This paper presents a modern review of the possibilities of using microRNA in the early diagnosis of BS.

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About the authors

Elena V. Reznik

Russian National Research Medical University named after N.I. Pirogov, Moscow

Email: elenaresnik@gmail.com
ORCID iD: 0000-0001-7479-418X
SPIN-code: 3494-9080

MD, Dr. Sci. (Medicine), Assistant Professor

Russian Federation, Moscow, Russia

Elvira A. Khachirova

Russian National Research Medical University named after N.I. Pirogov, Moscow

Email: Elchik09@mail.ru
ORCID iD: 0000-0003-2523-8907

Cand. Sci. (Med.), Pirogov Russian National Research Medical University

Russian Federation, Moscow, Russia

Maksim D. Iarovoi

Russian National Research Medical University named after N.I. Pirogov, Moscow

Email: jarovojmax@mail.ru
ORCID iD: 0009-0008-4580-8851
Russian Federation, Moscow, Russia

Victoria Yu. Voinova

Russian National Research Medical University named after N.I. Pirogov, Moscow

Author for correspondence.
Email: vivoinova@yandex.ru
ORCID iD: 0000-0001-8491-0228

д.м.н., руководитель

Russian Federation, Moscow, Russia

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