«Evaluation of the effectiveness of hypolipidemic therapy in patients with hypertriglyceridemia».



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Abstract

Relevance. The assertion that high blood triglyceride levels are an independent residual risk factor for cardiovascular pathologies has been controversial among cardiologists for decades. Associated with a high risk of developing cardiovascular complications, the increasement of triglyceride concentrations, hypertriglyceridemia, which is an imbalance in lipid parameters, plays a key role in modern studies of lipid metabolism. The effectiveness of lipid-lowering therapy is important in the management of cardiac patients.

Objective. To assess the effectiveness of lipid-lowering therapy in a population of cardiac patients aged 18-90 years with hypertriglyceridemia.

Materials and methods. The study was retrospective, the sample included 693 patients aged 18–90 years with a cardiological profile and hypertriglyceridemia. Clinical diagnoses were established based on medical records, anthropometric parameters, and laboratory test results.

Results. Lipid-lowering therapy was received by 459 (66.2%) subjects. Initiation of lipid-lowering therapy was required among 42 (6.1%) subjects. Therapy regimen adjustment was made in 184 (36.7%) patients taking medications. Target triglyceride levels were achieved among 309 (44.6%) patients, total cholesterol among 106 (15.3%) subjects, low-density lipoproteins among 201 (29%) subjects, high-density lipoproteins among 362 (52.2%) subjects, and target non-high-density lipoprotein cholesterol level in 186 (26.8%) subjects.

Conclusion. The effectiveness of lipid-lowering therapy among patients with hypertriglyceridemia was insufficient, which indicates the need for more aggressive pharmacotherapy of this lipid metabolism disorder in the management of cardiac patients. It is advisable to initiate and intensify triglyceride-lowering therapy in clinical practice and to increase physicians' awareness of this lipid metabolism disorder.

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About the authors

Aleksandr V. Shomin

LLC Group of Clinics "My Medical Center", Saint Petersburg; Federal State Budgetary Educational Institution of Higher Education "Saint Petersburg State University", Russian Federation.

Author for correspondence.
Email: survivorstar9@mail.ru
ORCID iD: 0000-0001-8620-5370
SPIN-code: 9074-1605
ResearcherId: rid64612

Assistant of the Department of Hospital Therapy at St. Petersburg State University, cardiologist at the My Medical Center Group of Clinics, St. Petersburg.

Russian Federation, Russian Federation, Saint Petersburg, Malaya Konyushennaya St., Building 8; Russian Federation, Saint Petersburg, 199034, Universitetskaya Nab., ​​7–9, Medical Institute.

Elena K. Serezhina

LLC Group of Clinics "My Medical Center", Saint Petersburg; Federal State Budgetary Educational Institution of Higher Education "Saint Petersburg State University", Russian Federation.

Email: zlotnikova.elena.konst@gmail.com
ORCID iD: 0000-0003-4239-9550
SPIN-code: 6436-7552
Scopus Author ID: 57218214175
ResearcherId: ACS-3089-2022

candidate of medical sciences, Assistant of the Department of Hospital Therapy at St. Petersburg State University, cardiologist at the My Medical Center Group of Clinics, St. Petersburg.

Russian Federation, Russian Federation, Saint Petersburg, Malaya Konyushennaya St., Building 8; Russian Federation, Saint Petersburg, 199034, Universitetskaya Nab., ​​7–9, Medical Institute.

Andrey G. Obrezan

LLC Group of Clinics "My Medical Center", Saint Petersburg; Federal State Budgetary Educational Institution of Higher Education "Saint Petersburg State University", Russian Federation.

Email: obrezan1@yandex.ru
ORCID iD: 0000-0001-6115-7923
SPIN-code: 4790-3880

Doctor of Medical Sciences, Professor and Head of the Department of Hospital Therapy at St. Petersburg State University, cardiologist at the My Medical Center Group of Clinics, St. Petersburg.

Russian Federation, Russian Federation, Saint Petersburg, Malaya Konyushennaya St., Building 8; Russian Federation, Saint Petersburg, 199034, Universitetskaya Nab., ​​7–9, Medical Institute.

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