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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">CardioSomatics</journal-id><journal-title-group><journal-title xml:lang="en">CardioSomatics</journal-title><trans-title-group xml:lang="ru"><trans-title>CardioСоматика</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2221-7185</issn><issn publication-format="electronic">2658-5707</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">139218</article-id><article-id pub-id-type="doi">10.17816/CS139218</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Reviews</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Обзоры</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">SFRP5 as a new cardiovascular biological marker: a literature review</article-title><trans-title-group xml:lang="ru"><trans-title>Использование SFRP5 в качестве нового сердечно-сосудистого биологического маркёра: обзор литературы</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5416-8579</contrib-id><contrib-id contrib-id-type="spin">2749-6427</contrib-id><name-alternatives><name xml:lang="en"><surname>Alieva</surname><given-names>Amina M.</given-names></name><name xml:lang="ru"><surname>Алиева</surname><given-names>Амина Магомедовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Med.)</p></bio><bio xml:lang="ru"><p>канд. мед. наук, доц., каф. госпитальной терапии им. акад. Г.И. Сторожакова, лечебный фак-т</p></bio><email>amisha_alieva@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7181-4680</contrib-id><contrib-id contrib-id-type="spin">9056-1948</contrib-id><name-alternatives><name xml:lang="en"><surname>Teplova</surname><given-names>Natalia V.</given-names></name><name xml:lang="ru"><surname>Теплова</surname><given-names>Наталья Вадимовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, D. Sci. (Med.)</p></bio><bio xml:lang="ru"><p>д-р мед. наук, проф., кафедра клинической фармакологии, лечебный фак-т</p></bio><email>teplova.nv@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0886-6290</contrib-id><contrib-id contrib-id-type="spin">3054-8884</contrib-id><name-alternatives><name xml:lang="en"><surname>Baykova</surname><given-names>Irina E.</given-names></name><name xml:lang="ru"><surname>Байкова</surname><given-names>Ирина Евгеньевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Med.)</p></bio><bio xml:lang="ru"><p>канд. мед. наук, доц., каф. госпитальной терапии им. акад. Г.И. Сторожакова, лечебный факультет</p></bio><email>1498553@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1111-6378</contrib-id><contrib-id contrib-id-type="spin">1636-7627</contrib-id><name-alternatives><name xml:lang="en"><surname>Voronkova</surname><given-names>Kira V.</given-names></name><name xml:lang="ru"><surname>Воронкова</surname><given-names>Кира Владимировна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, D. Sci. (Med.)</p></bio><bio xml:lang="ru"><p>д-р мед. наук, проф., каф. неврологии, фак-т дополнительного профессионального образования</p></bio><email>kiravoronkova@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3000-0987</contrib-id><contrib-id contrib-id-type="spin">5549-5823</contrib-id><name-alternatives><name xml:lang="en"><surname>Shnakhova</surname><given-names>Lidiya M.</given-names></name><name xml:lang="ru"><surname>Шнахова</surname><given-names>Лидия Мухамедовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>doctor consultant</p></bio><bio xml:lang="ru"><p>врач-консультант</p></bio><email>shnakhova_l_m@staff.sechenov.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0755-4869</contrib-id><name-alternatives><name xml:lang="en"><surname>Makeeva</surname><given-names>Lyudmila M.</given-names></name><name xml:lang="ru"><surname>Макеева</surname><given-names>Людмила Михайловна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Department Assist.</p></bio><bio xml:lang="ru"><p>ассистент, каф. госпитальной терапии им. акад. Г.И. Сторожакова, лечебный фак-т</p></bio><email>mila-mm@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5352-8499</contrib-id><contrib-id contrib-id-type="spin">1423-7300</contrib-id><name-alternatives><name xml:lang="en"><surname>Kotikova</surname><given-names>Irina A.</given-names></name><name xml:lang="ru"><surname>Котикова</surname><given-names>Ирина Александровна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>6th year student</p></bio><bio xml:lang="ru"><p>студентка 6-го курса лечебного фак-та</p></bio><email>kotikova.ia@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1699-0881</contrib-id><contrib-id contrib-id-type="spin">3595-1990</contrib-id><name-alternatives><name xml:lang="en"><surname>Nikitin</surname><given-names>Igor G.</given-names></name><name xml:lang="ru"><surname>Никитин</surname><given-names>Игорь Геннадиевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, D. Sci. (Med.), Prof.</p></bio><bio xml:lang="ru"><p>д-р мед. наук, проф. каф. госпитальной терапии им. акад. Г.И. Сторожакова, лечебный фак-т</p></bio><email>igor.nikitin.64@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Pirogov Russian National Research Medical University</institution></aff><aff><institution xml:lang="ru">ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Sechenov First Moscow State Medical University (Sechenov Unuiversity)</institution></aff><aff><institution xml:lang="ru">ФГАОУ ВО «Первый московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский университет)</institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2023-03-07" publication-format="electronic"><day>07</day><month>03</month><year>2023</year></pub-date><pub-date date-type="pub" iso-8601-date="2022-12-12" publication-format="electronic"><day>12</day><month>12</month><year>2022</year></pub-date><volume>13</volume><issue>4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>206</fpage><lpage>212</lpage><history><date date-type="received" iso-8601-date="2023-01-26"><day>26</day><month>01</month><year>2023</year></date><date date-type="accepted" iso-8601-date="2023-03-02"><day>02</day><month>03</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2023, Alieva A.M., Teplova N.V., Baykova I.E., Voronkova K.V., Shnakhova L.M., Makeeva L.M., Kotikova I.A., Nikitin I.G.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2023, Алиева А.М., Теплова Н.В., Байкова И.Е., Воронкова К.В., Шнахова Л.М., Макеева Л.М., Котикова И.А., Никитин И.Г.</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="en">Alieva A.M., Teplova N.V., Baykova I.E., Voronkova K.V., Shnakhova L.M., Makeeva L.M., Kotikova I.A., Nikitin I.G.</copyright-holder><copyright-holder xml:lang="ru">Алиева А.М., Теплова Н.В., Байкова И.Е., Воронкова К.В., Шнахова Л.М., Макеева Л.М., Котикова И.А., Никитин И.Г.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0/</ali:license_ref></license></permissions><self-uri xlink:href="https://cardiosomatics.ru/2221-7185/article/view/139218">https://cardiosomatics.ru/2221-7185/article/view/139218</self-uri><abstract xml:lang="en"><p>Research into new biological markers may help early diagnosis and effective therapy for cardiology patients. The use of biomarkers to evaluate patients has made a major impact in oncology, but is still in its infancy in the cardiology field. Studies on secreted frizzled-related protein 5 (SFRP5) have revealed its potential use as a marker of cardiovascular pathology. Preclinical studies have highlighted the important role this protein plays in many biological processes. It reduces the proliferation and migration of cardiac fibroblasts and suppresses the Wnt5A/JNK signaling pathway thus reducing the severity of oxidative stress and inflammation. It normalizes nitric oxide production and has several other effects. However, recent clinical studies of SFRP5 have produced conflicting data. Nevertheless, this protein shows promise as a marker for several metabolic and cardiovascular diseases. Preliminary data also suggest SFRP5 may be a therapeutic target. Further study of SFRP5 and its role in cardiovascular pathology is necessary, and will create new diagnostic and prognostic possibilities for this biological marker.</p></abstract><trans-abstract xml:lang="ru"><p>Исследования в области изучения новых биологических маркёров должны помочь в ранней диагностике и подборе более эффективной терапии для пациентов кардиологического профиля. В современном мире применение биомаркёров с целью идентификации пациентов основательно заняло свое место в онкологии, однако применение маркёров в области кардиологии пока что пребывает в состоянии начального становления. Проведённые к настоящему времени исследования, посвящённые SFRP5, свидетельствуют о возможности его использования в качестве маркёра сердечно-сосудистой патологии. Доклинические исследования подчёркивают важную позитивную роль этого белка во многих биологических процессах. Это и возможность снижения пролиферации и миграции сердечных фибробластов, и подавление сигнального пути Wnt5A/JNK, а, следовательно, уменьшение выраженности окислительного стресса и воспаления, нормализация продукции оксида азота и ряд других эффектов. В представленных клинических исследованиях в отношении SFRP5 встречаются противоречивые данные. Тем не менее этот белок может выступать маркёром ряда метаболических и сердечно-сосудистых заболеваний. Предварительные данные также позволяют рассматривать SFRP5 в качестве вероятной терапевтической мишени. Очевидно, что необходимо дальнейшее изучение SFRP5 и его роли при кардиоваскулярной патологии, что позволит открыть новые потенциальные диагностические и прогностические возможности этого биологического маркёра.</p></trans-abstract><kwd-group xml:lang="en"><kwd>biological marker</kwd><kwd>cardiovascular disease</kwd><kwd>SFRP5</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>биологические маркёры</kwd><kwd>сердечно-сосудистые заболевания</kwd><kwd>SFRP5</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Perk J. The 2016 version of the European Guidelines on Cardiovascular Prevention. Eur Heart J Cardiovasc Pharmacother. 2017;3(1):9–10.doi: 10.1093/ehjcvp/pvw030</mixed-citation><mixed-citation xml:lang="ru">Perk J. The 2016 version of the European Guidelines on Cardiovascular Prevention // Eur Heart J Cardiovasc Pharmacother. 2017. Vol. 3, N 1. 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