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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">CardioSomatics</journal-id><journal-title-group><journal-title xml:lang="en">CardioSomatics</journal-title><trans-title-group xml:lang="ru"><trans-title>CardioСоматика</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2221-7185</issn><issn publication-format="electronic">2658-5707</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">45175</article-id><article-id pub-id-type="doi">10.26442/CS45175</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">The role of calcium antagonists in the treatment of cardiovascular disease: Focus on diltiazem</article-title><trans-title-group xml:lang="ru"><trans-title>Роль антагонистов кальция в лечении сердечно-сосудистых заболеваний: фокус на дилтиазем</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Baryshnikova</surname><given-names>G. A</given-names></name><name xml:lang="ru"><surname>Барышникова</surname><given-names>Галина Анатольевна</given-names></name></name-alternatives><bio xml:lang="ru"><p>д-р мед. наук, проф. каф. семейной медицины ФГБУ УНМЦ Управления делами ПрезидентаРФ</p></bio><email>bargalan@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Chorbinskaya</surname><given-names>S. A</given-names></name><name xml:lang="ru"><surname>Чорбинская</surname><given-names>Светлана Алексеевна</given-names></name></name-alternatives><bio xml:lang="ru"><p>д-р мед. наук, проф., зав. каф. семейной медицины ФГБУ УНМЦ Управления делами Президента РФ</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Stepanova</surname><given-names>I. I</given-names></name><name xml:lang="ru"><surname>Степанова</surname><given-names>Ирина Ираклиевна</given-names></name></name-alternatives><bio xml:lang="ru"><p>канд. мед. наук, доц. каф. семейной медицины ФГБУ УНМЦ Управления делами Президента РФ</p></bio><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Teaching and Research Medical Center Office of the President of the Russian Federation, Moscow</institution></aff><aff><institution xml:lang="ru">ФГБУ Учебно-научный медицинский центр Управления делами Президента РФ, Москва</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2015-03-15" publication-format="electronic"><day>15</day><month>03</month><year>2015</year></pub-date><volume>6</volume><issue>1</issue><issue-title xml:lang="en">NO1 (2015)</issue-title><issue-title xml:lang="ru">ТОМ 6, №1 (2015)</issue-title><fpage>76</fpage><lpage>82</lpage><history><date date-type="received" iso-8601-date="2020-09-24"><day>24</day><month>09</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2015, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2015, ООО "Эко-Вектор"</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">ООО "Эко-Вектор"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://cardiosomatics.ru/2221-7185/article/view/45175">https://cardiosomatics.ru/2221-7185/article/view/45175</self-uri><abstract xml:lang="en"><p>The article deals with the use of calcium antagonists (CA) with a focus on diltiazem for the treatment of hypertension, angina pectoris, and cardiac arrhythmias, for secondary prevention of coronary heart disease, to evaluate their cardiac, angiography, nephroprotective effect, the ability to prevent the development of left ventricular hypertrophy. The problems of tolerability and safety of CA in short and prolonged action.</p></abstract><trans-abstract xml:lang="ru"><p>В статье рассматриваются вопросы использования антагонистов кальция (АК) с фокусом на дилтиазем для лечения артериальной гипертензии, стенокардии и нарушений ритма сердца, для вторичной профилактики ишемической болезни сердца, оценивается их кардио -, ангио -, нефропротективное действие, способность предупреждать развитие гипертрофии левого желудочка. Обсуждаются проблемы переносимости и безопасности АК короткого и пролонгированного действия.</p></trans-abstract><kwd-group xml:lang="en"><kwd>diltiazem</kwd><kwd>diltiazem long-acting calcium channel blockers</kwd><kwd>nedigidropiridinovy antagonists of calcium</kwd><kwd>hypertension</kwd><kwd>angina pectoris</kwd><kwd>myocardial infarction</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>дилтиазем</kwd><kwd>дилтиазем пролонгированного действия</kwd><kwd>антагонисты кальция</kwd><kwd>недигидропиридиновые антагонисты кальция</kwd><kwd>артериальная гипертония</kwd><kwd>стенокардия</kwd><kwd>инфаркт миокарда</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Fleckenstein A, Tritthart H, Fleckenstein B et al. Eineneue Gruppe - kompetitiver Ca++ Antagonisten (Iproveratril, D6000, Prenylamin) mitstarken Hemeffekten auf die elektromekanische Koppelungim Warmbluter - myocard. 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