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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">CardioSomatics</journal-id><journal-title-group><journal-title xml:lang="en">CardioSomatics</journal-title><trans-title-group xml:lang="ru"><trans-title>CardioСоматика</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2221-7185</issn><issn publication-format="electronic">2658-5707</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">45972</article-id><article-id pub-id-type="doi">10.26442/22217185.2018.4.000013</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Diagnosis and the debatable issues of the treatment of heart failure with preserved ejection fraction</article-title><trans-title-group xml:lang="ru"><trans-title>Диагностика и спорные вопросы лечения сердечной недостаточности с сохраненной фракцией выброса</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Akhilgova</surname><given-names>Z. M</given-names></name><name xml:lang="ru"><surname>Ахильгова</surname><given-names>Зарина Макшариповна</given-names></name></name-alternatives><bio xml:lang="ru"><p>аспирант</p></bio><email>Zarina.akhilgova@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kurkina</surname><given-names>M. V</given-names></name><name xml:lang="ru"><surname>Куркина</surname><given-names>Мария Владимировна</given-names></name></name-alternatives><email>mari.kurkina.1988@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Dzhioeva</surname><given-names>Z. R</given-names></name><name xml:lang="ru"><surname>Джиоева</surname><given-names>Зарина Ройоновна</given-names></name></name-alternatives><bio xml:lang="ru"><p>аспирант</p></bio><email>zarisha_dzhioeva@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Puhaeva</surname><given-names>A. A</given-names></name><name xml:lang="ru"><surname>Пухаева</surname><given-names>Алена Алексеевна</given-names></name></name-alternatives><bio xml:lang="ru"><p>канд. мед. наук, доц.</p></bio><email>alena_puhaeva@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Avtandilov</surname><given-names>A. G</given-names></name><name xml:lang="ru"><surname>Автандилов</surname><given-names>лександр Георгиевич</given-names></name></name-alternatives><bio xml:lang="ru"><p>д-р мед. наук, проф., зав. каф. терапии и подростковой медицины</p></bio><email>algav@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation</institution></aff><aff><institution xml:lang="ru">ФГБОУ ДПО РМАНПО</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2018-12-15" publication-format="electronic"><day>15</day><month>12</month><year>2018</year></pub-date><volume>9</volume><issue>4</issue><issue-title xml:lang="en">VOL 9, NO4 (2018)</issue-title><issue-title xml:lang="ru">ТОМ 9, №4 (2018)</issue-title><fpage>32</fpage><lpage>37</lpage><history><date date-type="received" iso-8601-date="2020-09-25"><day>25</day><month>09</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2018, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2018, ООО "Эко-Вектор"</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">ООО "Эко-Вектор"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/" start_date="2021-12-15"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://cardiosomatics.ru/2221-7185/article/view/45972">https://cardiosomatics.ru/2221-7185/article/view/45972</self-uri><abstract xml:lang="en"><p>Heart failure with preserved fraction (HFpEF) amount for a half of the general heart failure and increasing progressively. In this review we discuss the issues of pathogenesis of HFpEF, illuminated in the recent literature in the last years. Considering the heterogeneity of the pathophysiology of this syndrome and the results of large-scale studies conducted nowadays, it considers the debatable treatment issues of the applying different drugs in the prevention of HFpEF.</p></abstract><trans-abstract xml:lang="ru"><p>Сердечная недостаточность с сохраненной фракцией выброса (СНсФВ) составляет 1/2 от общего числа случаев сердечной недостаточности и продолжает прогрессивно расти. В обзоре обсуждаются вопросы патогенеза СНсФВ, освещенные в современной литературе за последние годы. Учитывая гетерогенность патофизиологии данного синдрома и результаты проведенных на сегодняшний день крупных исследований, рассматриваются спорные вопросы применения разных лекарственных препаратов в профилактике осложнений и прогрессирования СНсФВ.</p></trans-abstract><kwd-group xml:lang="en"><kwd>heart failure with preserved fraction</kwd><kwd>pathophysiology</kwd><kwd>prevention</kwd><kwd>treatment</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>сердечная недостаточность с сохраненной фракцией выброса</kwd><kwd>патофизиология</kwd><kwd>профилактика</kwd><kwd>лечение</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) Developed with the special contribution of the Heart Failure Association (HFA) of the ESC 2016. 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