CardioSomaticsCardioSomaticsCardioСоматика2221-71852658-5707Eco-Vector4603010.26442/22217185.2020.2.200226ReviewsОбзорыReview ArticleStatins and diabetes: focus on pitavastatinСтатины и сахарный диабет: фокус на питавастатинUrazgildeevaSoreiia A.УразгильдееваСорейя Асафовна
Russian Federation

D. Sci. (Med.), Saint Petersburg State University, Center for Clinical Lipidology of the Center of heart medicine “Chernaya Rechka”, Sokolov Clinical Hospital №122

д-р мед. наук, вед. науч. сотр. отд. атеросклероза НКиОЦ «Кардиология» ФГБОУ ВО СПбГУ, рук. Центра клинической липидологии Центра сердечной медицины «Черная Речка», кардиолог-консультант Центра атеросклероза и нарушений липидного обмена ФГБУЗ «КБ №122 им. Л.Г. Соколова»

docsau64@yandex.ruSaint Petersburg State UniversityФГБОУ ВО «Санкт-Петербургский государственный университет»Center for Clinical Lipidology of the Center of heart medicine «Chernaya Rechka»Центр клинической липидологии Центра сердечной медицины «Черная Речка»Sokolov Clinical Hospital №122ФГБУЗ «Клиническая больница №122 им. Л.Г. Соколова» ФМБА России2609202011240492609202026092020Copyright ©; 2020, Eco-VectorCopyright ©; 2020, ООО "Эко-Вектор"2020Eco-VectorООО "Эко-Вектор"https://creativecommons.org/licenses/by-nc-sa/4.0https://cardiosomatics.ru/2221-7185/article/view/46030

In this review, the focus is to investigate the effects of long-term statin therapy on glucose metabolism. The author analyzed the evidences of randomized clinical trials, meta-analyses, and experimental studies indicating the diabetogenic effect of the most of statins. Possible mechanisms of influence of statins on carbohydrate metabolism are presented. Particular attention is paid to the place of pitavastatin, due to its low diabetogenicity and minimal risk of drug interactions, as well as the need of taking into consideration the risk factors of diabetes and the preventive measures in patients receiving statin therapy.

Обзор посвящен проблеме развития нарушений углеводного обмена у пациентов, длительно принимающих статины. Проанализированы данные рандомизированных клинических исследований, метаанализов и экспериментальных работ, свидетельствующие о наличии диабетогенного эффекта у большинства статинов. Представлены возможные механизмы влияния терапии статинами на обмен углеводов. Особое внимание уделено месту питавастатина в контексте данной проблемы в связи с его низкой диабетогенностью и минимальным риском лекарственных взаимодействий, а также необходимости учета риск-факторов развития диабета у больных, получающих терапию статинами, и возможности его предотвращения.

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