The role of hypoglycemia in the development of cardiovascular catastrophes (experience of clinical studies)
Doskina E., Almazova I., Tanhilevich B.
摘要
According to the Clinical recommendations "Algorithms of specialized medical care for patients with diabetes mellitus", and receiving hypoglycemic therapy, it is advisable to start at a plasma glucose level <3.9 mmol/l. According to a prospective study, more than 85% of patients with DM1 recorded at least one confirmed hypoglycemic episode within 30 days. Numerous studies show that with DM1, an average of 0.5 to 5 severe hypoglycemic events are observed annually. The main cause of hypoglycemia is an excess of insulin in the body in relation to the intake of carbohydrates from the outside (with food) or from endogenous sources (production of glucose by the liver), as well as with accelerated utilization of carbohydrates (muscle work). Hypoglycemia causes reaction of the sympathetic nervous system, altered the morphology of the t wave, increased procoagulant state, inflammation, proterochampsa reaction, and endothelial dysfunction. Regular self-monitoring can reduce, and in some cases prevent the development of hypoglycemia.