Calcium-Ion Binding by Polymeric Alendronate Derivatives

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Abstract

Water-soluble phosphorus-containing polymers of various structures have been synthesized for the first time: a homopolymer of acryloyl alendronate, its copolymers with 4-acryloylmorpholine and 2-deoxy-2-methacrylamido-D-glucose, and a copolymer of N-vinylpyrrolidone with allyl alendronate. A comparative study of their ability to bind calcium ions has been conducted. It has been shown that for alendronate-containing polymers, the amount of Ca2+ bound by one phosphorus-containing group is 2 to 3 times higher than that of polyvinylphosphonic acid.

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About the authors

Т. N. Nekrasova

Konstantinov Saint Petersburg Institute of Nuclear Physics of the Kurchatov Institute

Author for correspondence.
Email: nazaro@hq.macro.ru
Russian Federation, Saint Petersburg

А. I. Fischer

Konstantinov Saint Petersburg Institute of Nuclear Physics of the Kurchatov Institute

Email: nazaro@hq.macro.ru
Russian Federation, Saint Petersburg

O. V. Nazarova

Konstantinov Saint Petersburg Institute of Nuclear Physics of the Kurchatov Institute

Email: nazaro@hq.macro.ru
Russian Federation, Saint Petersburg

E. P. Salikova

Konstantinov Saint Petersburg Institute of Nuclear Physics of the Kurchatov Institute

Email: nazaro@hq.macro.ru
Russian Federation, Saint Petersburg

Yu. I. Zolotova

Konstantinov Saint Petersburg Institute of Nuclear Physics of the Kurchatov Institute

Email: nazaro@hq.macro.ru
Russian Federation, Saint Petersburg

I. I. Gavrilova

Konstantinov Saint Petersburg Institute of Nuclear Physics of the Kurchatov Institute

Email: nazaro@hq.macro.ru
Russian Federation, Saint Petersburg

A. V. Dobrodumov

Konstantinov Saint Petersburg Institute of Nuclear Physics of the Kurchatov Institute

Email: nazaro@hq.macro.ru
Russian Federation, Saint Petersburg

M. A. Bezrukova

Konstantinov Saint Petersburg Institute of Nuclear Physics of the Kurchatov Institute

Email: nazaro@hq.macro.ru
Russian Federation, Saint Petersburg

E. F. Panarin

Konstantinov Saint Petersburg Institute of Nuclear Physics of the Kurchatov Institute

Email: nazaro@hq.macro.ru

Corresponding Member of the RAS

Russian Federation, Saint Petersburg

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Supplementary files

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2. Fig. 1. Structural formulae of the synthesised (co)polymers.

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3. Fig. 2. 1H NMR spectrum of the AALK-4-AM copolymer (70°C).

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4. Fig. 3. Dependence of bound Ca2+ concentration on the concentration of added Ca2+ in the (co)-polymer solution at spol = 1 mg ml-1: poly-AALK (curve 1), AALK-MAG (curve 2), AALK-4-AM (curve 3), and VP-AA (curve 4).

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