The effect of molixan, a disulfide-containing immunomodulator, on Na+ transport across frog skin epithelium

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Resumo

The effect of molixan, a disulfide-containing immunomodulator which is an analogue of oxidized glutathione, on Na+ transport across frog skin epithelium has been studied. Using the voltage-clamp technique, the capacity of molixan to modulate Na+ transport across frog skin epithelium has been revealed for the first time. It was also found that when molixan is applied to the apical surface of frog skin, it suppresses Na+ transport, while molixan added on the basolateral surface may mimic the effect of insulin and stimulate Na+ transport. The results obtained indicate that oxidized glutathione and its analogs molixan and glutoxim unidirectionally modulate Na+ transport across frog skin.

Sobre autores

A. Melnitskaya

Saint Petersburg State University

Email: a.melnitskaya@spbu.ru
Saint Petersburg, Russia

Z. Krutetskaya

Saint Petersburg State University

Saint Petersburg, Russia

V. Antonov

Saint Petersburg State Pediatric Medical University

Saint Petersburg, Russia

N. Krutetskaya

Saint Petersburg State University

Saint Petersburg, Russia

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