Mild Toxic Effect of Dinitrosyl Iron Complexes During Inhalation of Syrian Hamsters in a "Nose-Only" Chamber

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Resumo

Using methods of general and biochemical blood analysis and histological analysis of the lungs, liver, heart and kidneys of Syrian hamsters, it was checked whether aerosol treatment of these animals with binuclear dinitrosyl iron complexes with glutathione, alone or followed by similar treatment of the same animals with diethyldithiocarbonate, as well as aerosol treatment of Syrian hamsters with dinitrosyl iron complexes with mercaptosuccinate, leads to negative, toxic effects at the level of the whole organism. The detected weak, reversible toxic effect in the form of nephrotoxicity of such treatment allows us to assert that such an effect, which ensures the suppression of COVID infection in these animals, is due to the selective in vivo action of dinitrosyl iron complexes and diethyldithiocarbonate on the SARS-CoV-2 virus, without affecting other tissues and organs of the animal.

Sobre autores

S. Ankov

N.N. Vorozhtsov Institute for Organic Chemistry, Siberian Branch of the Russian Academy of Sciences

Email: sergey.ankov42@gmail.com
Novosibirsk, Russia

A. Shipovalov

State Research Center of Virology and Biotechnology VECTOR, Rosporrebnadzor of the Russian Federation

Novosibirsk, Russia

K. Bogatischeva

N.N. Vorozhtsov Institute for Organic Chemistry, Siberian Branch of the Russian Academy of Sciences

Novosibirsk, Russia

N. Zhukova

N.N. Vorozhtsov Institute for Organic Chemistry, Siberian Branch of the Russian Academy of Sciences

Novosibirsk, Russia

A. Vanin

N.N. Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences

Moscow, Russia

N. Tkachev

N.N. Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences

Moscow, Russia

O. Pyankov

State Research Center of Virology and Biotechnology VECTOR, Rosporrebnadzor of the Russian Federation

Novosibirsk, Russia

N. Asanbaeva

N.N. Vorozhtsov Institute for Organic Chemistry, Siberian Branch of the Russian Academy of Sciences

Novosibirsk, Russia

E. Bagryanskaya

N.N. Vorozhtsov Institute for Organic Chemistry, Siberian Branch of the Russian Academy of Sciences

Novosibirsk, Russia

Bibliografia

  1. Шиповалов А. В., Ванин А. Ф., Пьянков О. В., Багрянская Е. Г. и Попкова В. Я. Противовирусная активность катионов нитрозония в отношении SARS-CoV-2 на модели сирийских хомячков. Биофизика, 67, 969–981 (2022). doi: 10.31857/S0006302922050167, EDN: JJZIZA
  2. Шиповалов А. В., Ванин А. Ф., Ткачев Н. А., Пьянков О. В., Асанбаева Н. Б., Аньков С. В., Багрянская Е. Г., Бакланов А. М., Валиулин С. В. и Стекленева М. Е. Противовирусное действие в отношении SARS-CoV-2 растворов динитрозильных комплексов железа при их ингаляции сирийским хомячкам в «nose-only»-камере. Биофизика, 68 (6), 1318–1328 (2024). doi: 10.31857/S0006302924060176, EDN: NKUCHT
  3. Ottenweller J. E., Tapp W. N., Pitman D. L., and Natelson B. H. Interactions among the effects of aging, chronic disease, and stress on adrenocortical function in syrian hamsters. Endocrinology, 126 (1), 102–109 (1990). doi: 10.1210/endo-126-1-102
  4. Orcutt C. J. Common hamster diseases and treatment. In: Proc. North American Veterinary Conf. (2005), pp. 1358–1360.
  5. Мирошников М. В., Султанова К. Т., Ковалева М. А. и Макарова М. Н. Вариабельность биохимических показателей крови и установление референтных интервалов в доклинических исследованиях. Сообщение 8: сирийские хомячки. Лабораторные животные для научных исследований, № 2, 88–98 (2023). doi: 10.57034/2618723X-2023-02-08
  6. Washington I. M. and van Hoosier G. Clinical biochemistry and hematology. In: The laboratory rabbit, guinea pig, hamster, and other rodents. Ed. by M. A. Suckow, K. A. Stevens, and R. P. Wilson (Academic Press, 2012), pp. 57–116. doi: 10.1016/b978-0-12-380920-9.00003-1
  7. Lewandowska H., Stepkowski T. M., Meczinska-Wielgolz S., Sikorska K., Sadlo J., Dudek J., and Kruszewski M. LDL dinitrosyl iron complex as an iron donor in mouse macrophages. J. Inorg. Biochem., 188, 29–37 (2018). doi: 10.1016/j.jinorgbio.2018.08.004

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