Study of the effect of daily exposure to an electric insecticide vaporizer on the development of the body of white rats

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Abstract

Introduction. Electric insecticide vaporizer is a heating device, powered by the mains, when turned on this, the insecticidal agent, including the active substance, evaporates into the air of the treated room. The population uses an electric insecticide vaporizer during the warm season to destroy flying blood-sucking insects, which, in addition to epidemiological danger, creates psychological discomfort at night. Highly volatile pyrethroids are used as active ingredients in insecticidal electric vaporizer agents, which have an adverse effect on the nervous system, liver and urinary system. It is also becoming urgent the problem of air pollution indoor, especially for children.

Materials and methods. Toxicological methods for assessing the danger of using insecticidal agents; biochemical methods for the study of blood serum.

Results. There was studied a long-term inhalation effect of an electric insecticide vaporizer based on transfluthrin on the functional state of white rats. The agent was established to have an effect on the number of eosinophils in the blood, indicating to the development of allergic responses in the body of rats; affects the function of the nervous system, which confirms the literature data; disrupts metabolic processes in the liver, manifested in a change in individual indicators (carbohydrate, protein metabolism, creatinine synthesis).

Limitations. In our study, there are no data on the study of organ tissues, nor have we studied the processes of cell damage as a result of oxidative stress.

Conclusion. Based on the conducted studies, physiological and biochemical biomarkers of the effect of an electric vaporizer with transfluthrin were established. Continuous long-term use of electric insecticide vaporizer can have a harmful effect on the body. The use of these products in ventilated areas according to the consumption rate is safe.

To identify the toxic effect of inhalation exposure to transfluthrin, 80 outbred white rats were examined in terms of parameters characterizing the functions of the nervous, respiratory systems, liver, kidneys, and peripheral blood composition.

Contribution:

Gololobova T.V. — approval of the final version of the article;

Bidevkina M.V. — concept and design of the study, editing, approval of the final version of the article, responsibility for the integrity of all parts of the article;

Vinogradova A.I. — concept and design of the study, collection and processing of material, statistical processing, writing text;

Matrosenko M.V. — statistical processing. All authors are responsible for the integrity of all parts of the manuscript and approval of the manuscript final version

Conflict of interest. The authors declare no conflict of interest.

Acknowledgement. The was carried out as part of the sectoral research program of Federal Service for Supervision in Protection of the Rights of Consumer and Man Wellbeing for 2016–2020.

Received: October 4, 2021 / Accepted: November 25, 2021 / Published: April 08, 2022

About the authors

Tatiana V. Gololobova

Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation

Author for correspondence.
Email: noemail@neicon.ru
ORCID iD: 0000-0001-9033-5223
Russian Federation

Arina I. Vinogradova

Federal Scientific Center of Hygiene named after F.F. Erisman of the Federal Service for Supervision in Protection of the Rights of Consumer and Man Wellbeing

Email: vinney93@mail.ru
ORCID iD: 0000-0002-3253-4571

Researcher, Laboratory of Toxicology, Scientific Research Disinfectology Institute of the Federal Service for Supervision in Protection of the Rights of Consumer and Man Wellbeing, Moscow, 117246, Russian Federation.

e-mail: vinney93@mail.ru

Russian Federation

Marina V. Bidevkina

Federal Scientific Center of Hygiene named after F.F. Erisman of the Federal Service for Supervision in Protection of the Rights of Consumer and Man Wellbeing

Email: noemail@neicon.ru
ORCID iD: 0000-0001-6433-899X
Russian Federation

Margarita V. Matrosenko

Federal Scientific Center of Hygiene named after F.F. Erisman of the Federal Service for Supervision in Protection of the Rights of Consumer and Man Wellbeing

Email: noemail@neicon.ru
ORCID iD: 0000-0003-0567-2247
Russian Federation

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