Preparation of suspension of nanodiamonds with immobilized scandium isotopes for in vivo research

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Resumo

The conditions for preparing a suspension of detonation synthesis nanodiamonds (NDs) with immobilized scandium in solutions that meet the requirements to solutions for intravenous administration of radiopharmaceuticals (RPs) based on 44Sc and 47Sc are determined. The possibility of quantitatively binding scandium by ND samples in isotonic solutions with the required pH, containing a minimum amount of NDs, is demonstrated. The parameters of the Freundlich and Langmuir adsorption isotherms and ΔG of adsorption under optimal conditions for the most promising ND sample are determined. The conditions found for obtaining NDs with immobilized scandium isotopes will allow further in vivo researches.

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Sobre autores

A. Kazakov

Vernadsky Institute of Geochemistry and Analytical Chemistry, RAS

Autor responsável pela correspondência
Email: adeptak92@mail.ru
Rússia, Moscow

D. Pavlova

Vernadsky Institute of Geochemistry and Analytical Chemistry, RAS; Mendeleev University of Chemical Technology of Russia

Email: adeptak92@mail.ru
Rússia, Moscow; Moscow

I. Ushakov

National Research Tomsk Polytechnic University

Email: adeptak92@mail.ru
Rússia, Tomsk

E. Nesterov

National Research Tomsk Polytechnic University

Email: adeptak92@mail.ru
Rússia, Tomsk

V. Skuridin

National Research Tomsk Polytechnic University

Email: adeptak92@mail.ru
Rússia, Tomsk

E. Odintsova

Bentonit Company

Email: adeptak92@mail.ru
Rússia, Moscow

S. Vinokurov

Vernadsky Institute of Geochemistry and Analytical Chemistry, RAS

Email: adeptak92@mail.ru
Rússia, Moscow

B. Myasoedov

Vernadsky Institute of Geochemistry and Analytical Chemistry, RAS; Interdepartmental Center for Analytical Research in Physics, Chemistry, and Biology, RAS

Email: adeptak92@mail.ru
Rússia, Moscow; Moscow

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2. Fig. 1. Kinetics of scandium sorption (440 ng) by NA samples (100 μg/ml) at pH 2, 3, 4 and 5 (a–g, respectively).

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3. Fig. 2. Equilibrium values ​​of the degree of scandium sorption (5 μg) by the RUDDM sample at pH 4.0 in 0.9% NaCl from 1 ml of solution.

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4. Fig. 3. Freundlich (a) and Langmuir (b) adsorption isotherms for scandium sorption by a RUDDM sample in 0.9% NaCl with pH 4.0.

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5. Fig. 4. Presentation of experimental data and obtained adsorption isotherms in Qe–Ce coordinates.

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6. Fig. 5. Dependence of ln(Qe/Ce) on Qe during scandium sorption by RUDDM in 0.9% NaCl with pH 4.0.

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