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The influence of the sizes of nanodiamond aggregates in their suspensions on the efficiency of sorption of 90Y and 177Lu isotopes for their subsequent use in nuclear medicine
- Authors: Kazakov A.G.1, Babenya J.S.1, Ekatova T.Y.1, Vinokurov S.E.1, Khvorostinin E.Y.1, Ushakov I.A.2, Zukau V.V.2, Stasyuk E.S.2, Nesterov E.A.2, Sadkin V.L.2, Rogov A.S.2, Myasoedov B.F.1,3
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Affiliations:
- Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences
- National Research Tomsk Polytechnic University
- Interdepartmental Center for Analytical Research in Physics, Chemistry and Biology, Russian Academy of Sciences
- Issue: Vol 66, No 2 (2024)
- Pages: 178-184
- Section: Articles
- URL: https://cardiosomatics.ru/0033-8311/article/view/661162
- DOI: https://doi.org/10.31857/S0033831124020093
- ID: 661162
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Abstract
Nanodiamonds (NDs) are promising carriers of radionuclides in radiopharmaceuticals for use in nuclear medicine. In this work, we investigated the influence of the properties of ND suspensions, including the sizes of their aggregates, in aqueous solutions with different pH on their binding of medical isotopes 90Y and 177Lu and found the conditions for obtaining promising conjugates for further in vivo studies. It was shown that sorption is influenced by the composition of the solution, which determines the properties of the ND surface, while the forms of cations of the studied nuclides in the solution do not affect the degree of sorption.
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About the authors
A. G. Kazakov
Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences
Author for correspondence.
Email: adeptak92@mail.ru
Russian Federation, Moscow
J. S. Babenya
Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences
Email: adeptak92@mail.ru
Russian Federation, Moscow
T. Y. Ekatova
Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences
Email: adeptak92@mail.ru
Russian Federation, Moscow
S. E. Vinokurov
Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences
Email: adeptak92@mail.ru
Russian Federation, Moscow
E. Y. Khvorostinin
Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences
Email: adeptak92@mail.ru
Russian Federation, Moscow
I. A. Ushakov
National Research Tomsk Polytechnic University
Email: adeptak92@mail.ru
Russian Federation, Tomsk
V. V. Zukau
National Research Tomsk Polytechnic University
Email: adeptak92@mail.ru
Russian Federation, Tomsk
E. S. Stasyuk
National Research Tomsk Polytechnic University
Email: adeptak92@mail.ru
Russian Federation, Tomsk
E. A. Nesterov
National Research Tomsk Polytechnic University
Email: adeptak92@mail.ru
Russian Federation, Tomsk
V. L. Sadkin
National Research Tomsk Polytechnic University
Email: adeptak92@mail.ru
Russian Federation, Tomsk
A. S. Rogov
National Research Tomsk Polytechnic University
Email: adeptak92@mail.ru
Russian Federation, Tomsk
B. F. Myasoedov
Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences; Interdepartmental Center for Analytical Research in Physics, Chemistry and Biology, Russian Academy of Sciences
Email: adeptak92@mail.ru
Russian Federation, Moscow; Moscow
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