The influence of the sizes of nanodiamond aggregates in their suspensions on the efficiency of sorption of 90Y and 177Lu isotopes for their subsequent use in nuclear medicine

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Resumo

Nanodiamonds (NDs) are promising carriers of radionuclides in radiopharmaceuticals for use in nuclear medicine. In this work, we investigated the influence of the properties of ND suspensions, including the sizes of their aggregates, in aqueous solutions with different pH on their binding of medical isotopes 90Y and 177Lu and found the conditions for obtaining promising conjugates for further in vivo studies. It was shown that sorption is influenced by the composition of the solution, which determines the properties of the ND surface, while the forms of cations of the studied nuclides in the solution do not affect the degree of sorption.

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Sobre autores

A. Kazakov

Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences

Autor responsável pela correspondência
Email: adeptak92@mail.ru
Rússia, Moscow

J. Babenya

Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences

Email: adeptak92@mail.ru
Rússia, Moscow

T. Ekatova

Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences

Email: adeptak92@mail.ru
Rússia, Moscow

S. Vinokurov

Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences

Email: adeptak92@mail.ru
Rússia, Moscow

E. Khvorostinin

Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences

Email: adeptak92@mail.ru
Rússia, Moscow

I. Ushakov

National Research Tomsk Polytechnic University

Email: adeptak92@mail.ru
Rússia, Tomsk

V. Zukau

National Research Tomsk Polytechnic University

Email: adeptak92@mail.ru
Rússia, Tomsk

E. Stasyuk

National Research Tomsk Polytechnic University

Email: adeptak92@mail.ru
Rússia, Tomsk

E. Nesterov

National Research Tomsk Polytechnic University

Email: adeptak92@mail.ru
Rússia, Tomsk

V. Sadkin

National Research Tomsk Polytechnic University

Email: adeptak92@mail.ru
Rússia, Tomsk

A. Rogov

National Research Tomsk Polytechnic University

Email: adeptak92@mail.ru
Rússia, Tomsk

B. Myasoedov

Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences; Interdepartmental Center for Analytical Research in Physics, Chemistry and Biology, Russian Academy of Sciences

Email: adeptak92@mail.ru
Rússia, Moscow; Moscow

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2. Fig. 1. Sizes of the aggregates of the studied NA (a) and their ζ-potential (b) in HCl and NH3 solutions

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3. Fig. 2. The degree of sorption of 90Y by HA samples from aqueous solutions for 30 min (a) and the Y(III) form, calculated using CHEAQS [19] for the corresponding concentrations of reagents (b).

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4. Fig. 3. The degree of sorption of 90Y in 30 min and the size of HA aggregates depending on pH by TAN (a), ok-TAN (b), STP (c) and ok-STP (d) samples.

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5. Fig. 4. The degree of sorption of 177Lu by NA samples from aqueous solutions for 30 min (a) and Lu(III) forms calculated using CHEAQS [19] for the corresponding reagent concentrations (b).

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6. Fig. 5. The degree of sorption of 177Lu in 30 min and the size of HA aggregates depending on pH by TAN (a), STP (b) and ok-STP (c) samples.

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