Functional Design Of Peroral Delivery Systems Based On Polymethylsesquoxane Hydrogels For The Therapy Of Iron Deficiency Anemia

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Аннотация

Anemia is a prevalent circulatory system illness that is severely harmful to patients. The development of novel oral delivery systems for iron compounds with enhanced biopharmaceutical properties is vital considering the severe side effects associated with oral medication use. We believe incorporating iron compounds to polymethylsilsesquioxane hydrogels is a promising approach. According to previously published materials, such a system should have great biocompatibility and a capacity for iron compounds, and it may be able to release contents into the intestine. This study investigated polymethysilsesquioxane hydrogels with varying silicate unit concentrations. Potential iron-containing medicines were iron(III) chloride (FeCl3∙6H2O)) and iron(II) D-gluconate. All hydrogels were found to have nearly 100% sorption activity for a saturated solution of FeCl3∙6H2O (0.27 M) during the experiment, but only around 30% sorption capacity was found for a saturated solution of D-gluconate (0.24 M). A specific field of study was the distribution of iron atoms within hydrogels. It has been established that the largest regions devoid of iron atoms are observed in a hydrogel with a maximum quantity of inorganic units. The outcomes provide opportunities for the precise engineering of polymer matrix structures for iron compound delivery.

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Авторлар туралы

P. Orlova

Lomonosov Moscow State University

Email: i.m.deygen@gmail.com

Faculty of fundamental physico-chemical engineering, Faculty of chemistry

Ресей, Moscow, 119991

I. Meshkov

Institute of synthetic polymer materials

Email: i.m.deygen@gmail.com
Ресей, Moscow, 117393

E. Latipov

Institute of nanotechnology electronics

Email: i.m.deygen@gmail.com
Ресей, Moscow, 115487

S. Vasiliev

Federal Research Center for Problems of Chemical Physics and Medicinal Chemistry

Email: i.m.deygen@gmail.com
Ресей, Chernogolovka, 142432

A. Kalinina

Institute of synthetic polymer materials

Email: i.m.deygen@gmail.com
Ресей, Moscow, 117393

A. Muzafarov

Institute of synthetic polymer materials

Email: i.m.deygen@gmail.com
Ресей, Moscow, 117393

I. Le-Deygen

Lomonosov Moscow State University

Хат алмасуға жауапты Автор.
Email: i.m.deygen@gmail.com

Faculty of chemistry

Ресей, Moscow, 119991

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1. JATS XML
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2. Application
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3. Fig. 1. Complete scheme of synthesis of PMSSO-hydrogels.

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4. Fig. 2. Structure and NMR spectrum of 29Si PMSSOL.

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5. 3. Structures and NMR spectra of 29Si hydrogels 1 (a), 2 (b) and 3 (c).

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6. Fig. 4. IR spectra of NPVO hydrogels in water at 22oC. Hydrogels 1 and 2 contain additional units of SiO · 0.5OH and SiO2 in their structure.

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7. Fig. 5. UV spectrum of FeCl3 × 6H2O solution, pH 4.0 (0.1 mM HCl), C(Fe3+) = 7 × 10-5 mol/L, 22°C (a). Calibration curve of FeCl3 × 6H2O under the same conditions (b).

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8. 6. IR spectrum of iron D-gluconate solution, pH 4.0 (0.1 mM HCl), C(Fe2+) = 0.01 mol/L, 22°C (a). Calibration curve of iron D-gluconate under the same conditions (b).

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9. 7. Sorption curves of PMCC hydrogels with respect to iron D-gluconate in the concentration range from 0.0024 to 0.24 mol/l, pH 4.0 (0.1 mM HCl), 22°C.

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10. 8. SEM (a) and ERS are the distribution of iron atoms (b) 10-4 M FeCl3 × 6H2O in hydrogel 1; SEM (c) and ERS are the distribution of iron atoms (d) 0.1 M iron D-gluconate in hydrogels 1 (e) and 2 (e).

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11. 9. IR spectra of 10-4 M FeCl3 × 6H2O (a) and 0.1 M iron D-gluconate (b) in hydrogel 1.

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