Synthesis and study of some properties of new tetrazole-containing derivatives of morpholin-4-yl-1,3,5-triazine and 4-methylpiperidin-1-yl-1,3,5-triazine

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Resumo

New tetrazole-containing derivatives of morpholin-4-yl-1,3,5-triazine and 4-methylpiperidin-1-yl-1,3,5-triazine were synthesized. Cytotoxic activity of the compounds obtained against human liver tumor cell lines Huh-7 and human lung A549 was studied by the MTT test. It was shown that these substances do not exhibit a pronounced cytotoxic effect. The most significant antitumor activity was shown by 1,3,5-triazine containing 5-phenyltetrazol-2-ylacetohydrazide fragment and 4-methylpiperidine ring as substituents, as well as 1,3,5-triazine containing 5-methyl-1 H -tetrazol-1-ylacetohydrazide fragment and two morpholine rings. For these compounds, the interaction with DNA was studied by UV spectroscopy. For N ’-(4,6-dimorpholino-1,3,5-triazin-2-yl)-2-(5-methyl-1 H -tetrazol-1-yl)acetohydrazide, the DNA binding constant was determined ( K bin 9.02× 104 M.-1) and studied the ability to inhibit the tyrosine kinase domain of surface receptors. It was shown that the studied tetrazole-containing derivatives of 1,3,5-triazine do not exhibit antioxidant properties with respect to NO-radicals and do not cause photoinduced hemolysis.

Sobre autores

O. Mykolaichuk

I.P. Pavlov First St. Petersburg State Medical University;Academician A. M. Granov Russian Research Center for Radiology and Surgical Technologies, Ministry of Health of the Russian Federation

Email: olgamedchem@gmail.com

A. Protas

I.P. Pavlov First St. Petersburg State Medical University;Academician A. M. Granov Russian Research Center for Radiology and Surgical Technologies, Ministry of Health of the Russian Federation

E. Popova

I.P. Pavlov First St. Petersburg State Medical University;Academician A. M. Granov Russian Research Center for Radiology and Surgical Technologies, Ministry of Health of the Russian Federation

M. Lutsev

I.P. Pavlov First St. Petersburg State Medical University

E. Smirnov

State Research Institute of Lake and River Fisheries;Institute of Cytology, Russian Academy of Sciences

V. Golotin

I.P. Pavlov First St. Petersburg State Medical University;State Research Institute of Lake and River Fisheries

V. Ostrovsky

St. Petersburg State Institute of Technology (Technical University)

I. Kornyakov

St. Petersburg State University

K. Semenov

I.P. Pavlov First St. Petersburg State Medical University;Academician A. M. Granov Russian Research Center for Radiology and Surgical Technologies, Ministry of Health of the Russian Federation;St. Petersburg State Institute of Technology (Technical University);St. Petersburg State University

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