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Search for Monoamine Oxidase Inhibitors among Pyrazoline and Pyrimidine Derivatives and Studying Luminescent Properties of the Obtained Compounds
- Authors: Isakhanyan A.U.1, Hakobyan N.Z.1, Hovasyan Z.A.1, Grigoryan G.S.2, Mkhitaryan R.P.2, Yesayan D.L.2, Grigoryan A.S.1, Gasparyan H.V.1, Panosyan Н.A.1, Harutyunyan A.A.1
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Affiliations:
- Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
- Yerevan State University
- Issue: Vol 94, No 1 (2024)
- Pages: 80-91
- Section: Articles
- URL: https://cardiosomatics.ru/0044-460X/article/view/667235
- DOI: https://doi.org/10.31857/S0044460X24010065
- EDN: https://elibrary.ru/HLHZQA
- ID: 667235
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Abstract
Cyclization of the (E)-3-aryl-1-(4-alkoxyphenyl)prop-2-en-1-ones with phenylhydrazine in an acidic medium leads to the 5-aryl-3-(4-alkoxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazoles. Bubbling air through a solution of 5-(4-methoxyphenyl)-1-phenyl-3-(4-ethoxyphenyl)-4,5-dihydro-1H-pyrazole in ethylcellosolve resulted in an oxidation-dehydrogenation product, which characterized as the picrate of the corresponding pyrazole. The reaction of benzamidine and 4-methylbenzamidine hydrochlorides with substituted chalcones in а KOH–ethanol system leads to 2,4-diaryl-6-(4-alkoxyphenyl)pyrimidines. The luminescent and antimonoamine oxidase properties of the resulting systems were studied.
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About the authors
A. U. Isakhanyan
Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
Author for correspondence.
Email: anush.isakhanyan.51@mail.ru
ORCID iD: 0000-0002-1713-4908
Armenia, Yerevan
N. Z. Hakobyan
Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
Email: anush.isakhanyan.51@mail.ru
ORCID iD: 0000-0002-3095-5938
Armenia, Yerevan
Z. A. Hovasyan
Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
Email: anush.isakhanyan.51@mail.ru
ORCID iD: 0000-0001-6698-7184
Armenia, Yerevan
G. S. Grigoryan
Yerevan State University
Email: gevsgrig@ysu.am
ORCID iD: 0000-0002-0675-735X
Armenia, Yerevan
R. P. Mkhitaryan
Yerevan State University
Email: gevsgrig@ysu.am
ORCID iD: 0009-0009-6277-2747
Armenia, Yerevan
D. L. Yesayan
Yerevan State University
Email: gevsgrig@ysu.am
ORCID iD: 0009-0008-7243-6248
Russian Federation, Yerevan
A. S. Grigoryan
Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
Email: anush.isakhanyan.51@mail.ru
ORCID iD: 0000-0002-3834-3338
Russian Federation, Yerevan
H. V. Gasparyan
Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
Email: anush.isakhanyan.51@mail.ru
ORCID iD: 0000-0002-8555-3733
Russian Federation, Yerevan
Н. A. Panosyan
Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
Email: anush.isakhanyan.51@mail.ru
ORCID iD: 0000-0001-8311-6276
Russian Federation, Yerevan
A. A. Harutyunyan
Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
Email: anush.isakhanyan.51@mail.ru
ORCID iD: 0000-0003-0641-5453
Russian Federation, Yerevan
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