Synthesis, luminescent properties and antibacterial activity of new pyrazoline and pyrimidine derivatives of (2e)-1-biphenyl-3-arylprop-2-en-1-ones

Мұқаба

Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Тек жазылушылар үшін

Аннотация

Substituted prop-2-en-1-ones were obtained by the condensation reaction of 1-biphenyl-4-yl-ethanone with aromatic aldehydes in the presence of sodium hydroxide in an aqueous ethanol solution. Subsequent cyclization of the latter with hydrazine hydrate, phenylhydrazine, and thiosemicarbazide in an acidic medium leads to the corresponding pyrazolines. The reaction of amidine hydrochlorides with chalcones in a KOH-ethanol system leads to 2,4,6-trisubstituted pyrimidines. The luminescent and antibacterial properties of the resulting systems was studied.

Авторлар туралы

A. Isakhanyan

Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

Email: anush.isakhanyan.51@mail.ru

N. Hakobyan

Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

Z. Hovasyan

Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

G. Grigoryan

Yerevan State University

R. Mkhitaryan

Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

H. Aracelyan

Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

A. Safaryan

Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

R. Muradyan

Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

H. Panosyan

Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

Әдебиет тізімі

  1. Li J.-T., Zhang X.-H., Lin Z.-P. // Beilstein J. Org. Chem. 2007. Vol. 3. N 13. doi: 10.1186/1860-5397-3-13
  2. Li Q.S., Shen B.N., Zhang Z., Luo S., Ruan B.F. // Curr. Med. Chem. 2021. Vol. 28. N 5. P. 940. doi: 10.2174/0929867327666200306120151
  3. Patil S.B. // Int. J. Pharm. Sci. Res. 2018. Vol. 9. N 1. P. 44. doi: 10.13040/IJPSR.0975-8232.9(1).44-52
  4. Elkanzi N.A.A. // Orient. J. Chem. 2020. Vol. 36. N 6. P. 1001. doi: 10.13005/ojc/360602
  5. Sviripa V.M., Zhang W., Balia A.G., Tsodikov O.V., Nickell J.R., Gizard F., Yu T., Lee E.Y., Dwoskin L.P., Watt D.S. // J. Med. Chem. 2014. Vol. 57. P. 6083. doi: 10.1021/jm5004864
  6. Varghese B., Al-Busafi S.N., Suliman F.O., AlKindy S.M.Z. // RSC Adv. 2017. Vol. 7. P. 46999. doi: 10.1039/C7RA08939B
  7. Selivanova D.G., Gorbunov A.A., Mayorova O.A., Vasyanin A.N., Lunegov I.V., Shklyaeva E.V., Abashev G.G. // Beilstein J. Org. Chem. 2017. Vol. 13. P. 1583. doi: 10.3762/bjoc.13.158.
  8. Achelle S., Rodríguez-Lopez J., Larbani M., Plaza-Pedroche R., Robin-le Guen F. // Molecules. 2019. Vol. 24. P. 1742. doi: 10.3390/molecules24091742
  9. Shivananda M.K., Holla B.S. // J. Chem. Pharm. Res. 2017. Vol. 9. N 6. P. 1.
  10. Руководство по проведению доклинических исследований лекарственных средств / Под ред. А.Н. Миронова. М.: Медицина, 2012. С. 509.
  11. Машковский М.Д. Лекарственные средства. М.: Новая волна, 2010. С. 851.

Қосымша файлдар

Қосымша файлдар
Әрекет
1. JATS XML
Жүктеу

© Russian Academy of Sciences, 2023