Microbiota-associated diseases as an endotoxin-initiated pathology or intestinal factor in the induction of systemic inflammation and progression of aging

Capa

Citar

Texto integral

Acesso aberto Acesso aberto
Acesso é fechado Acesso está concedido
Acesso é fechado Somente assinantes

Resumo

The intestinal microbiota is a vital organ – a participant in the processes of adaptation and evolution, an inducer of inflammation and the progression of aging. The key element of the interaction of intestinal microbiota with the body is lipopolysaccharides, the level of which in the general bloodstream increases significantly in so-called “microbiota-associated diseases”, which indicates the participation of endotoxin aggression in their pathogenesis, and most likely their initiation. One of the most common reasons for the development of endotoxin aggression may be quantitative and qualitative changes in the structure of the intestinal microbiota, leading to an increase in intestinal permeability, which are largely determined by nutritional factors. The antiendotoxin component in the treatment regimen for patients with various nosological forms of the diseases significantly increases the effectiveness of the treatment and prophylactic process, which can become one of the most promising areas of anti-aging measures.

Texto integral

Acesso é fechado

Sobre autores

S. Morozov

Research Institute of General Pathology and Pathophysiology

Autor responsável pela correspondência
Email: sergey_moroz@list.ru
Rússia, Moscow

A. Sozinov

Kazan State Medical University

Email: sergey_moroz@list.ru
Rússia, Kazan

M. Iakovlev

Research Institute of General Pathology and Pathophysiology

Email: yakovlev-lps@yandex.ru
Rússia, Moscow

Bibliografia

  1. Mechnikov I.I. [Sketches about human nature]. Moscow: Nauka, 1961. 290 р.
  2. Yakovlev M.Yu. Role of intestinal microflora and insufficient barrier function of the liver in the development of endotoxinemia and inflammation // Kazan Med. J. 1988. V. 69. № 5. P. 353.
  3. Anikhovskaya I.A., Beloglazov V.A., Gordienko A.I. et al. [A brief history of studying the role of intestinal factor in aging and/or induction of systemic inflamation: Achievements, challenges, and prospects] // Patogenez (Pathogenesis). 2019. V. 17. № 1. P. 4.
  4. Medzhitov R., Janeway C.A., Jr. Innate immunity: impact on the adaptive immune response // Curr. Opin. Immunol. 1997. V. 9. № 1. P. 4.
  5. Medzhitov R., Janeway C.A., Jr. Innate immunity: the virtues of a nonclonal system of recognition // Cell. 1999. V. 91. № 3. P. 295.
  6. Medzhitov R., Preston-Hurlburt P., Janeway C.A., Jr. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity // Nature. 1997. V. 388. № 6640. P. 394.
  7. Yakovlev M.Yu. [Sistemnaya endotoksinemiya: gomeostaz i obshchaya patologiya] (Systemic Endotoxinemia: Homeostasis and General Pathology). Moscow: Nauka, 2021. 182 p.
  8. Bogadelnikov I.V., Samokhvalov V.P. [Microbiome and psychosphere]. Simferopol: IT "ARIAL", 2020. 312 p.
  9. Bukharin O.V., Perunova N.B. [The role of microbiota in the regulation of homeostasis in the human body during infection] // Zh. Mikrobiol. Epidemiol. Immunobiol. (J. Microbiol. Epidemiol. Immunobiol.). 2020. V. 97. № 5. P. 458.
  10. Bäckhed F., Roswall J., Peng Y. et al. Dynamics and stabilization of the human gut microbiome during the first year of life // Cell Host Microbe. 2015. V. 17. № 5. P. 690.
  11. Doroszkiewicz J., Groblewska M., Mroczko B. The role of gut microbiota and gut–brain interplay in selected diseases of the central nervous system // Int. J. Mol. Sci. 2021. V. 22. № 18. P. 10028.
  12. Fallani M., Young D., Scott J. et al. Intestinal microbiota of 6-week-old infants across Europe: geographic influence beyond delivery mode, breast-feeding, and antibiotics // J. Pediatr. Gastroenterol. Nutr. 2010. V. 51. № 1. P. 77.
  13. Urazaev R.A., Krupnik A.N., Yakovlev M.Yu. Endotoxinemia in early period of adaptation in infants and their mothers // Kazan Med. J. 1992. V. 73. № 2. P. 114.
  14. García-Peña C., Álvarez-Cisneros T., Quiroz-Baez R., Friedland R.P. Microbiota and aging. A review and commentary // Arch. Med. Res. 2017. V. 48. № 8. P. 681.
  15. Anikhovskaya I.A., Vyshegurov Ya.Kh., Usov I.A., Yakovlev M.Yu. Bifidobacteria as a means of prevention or treatment of endotoxin aggression in patients with chronic diseases during remission or exarcerbation // Human Physiology. 2004. V. 30. № 6. P. 732.
  16. Flint H.J., Scott K.P., Louis P., Duncan S.H. The role of the gut microbiota in nutrition and health // Nat. Rev. Gastroenterol. Hepatol. 2012. V. 9. № 10. P. 577.
  17. OkorokovP.L., Anikhovskaya I.A., Yakovleva M.M. et al. Nutritional factors of inflammation induction or lipid mechanism of endotoxin transport // Human Physiology. 2012. V. 38. № 6. P. 649.
  18. Anikhovskaya I.A., Kubatiev A.A., Maisky I.A. et al. [The search direction means for reducing endotoxin concentration in the general haemocirculation] // Patogenez (Pathogenesis). 2014. V. 12. № 4. P. 25.
  19. Anikhovskaya I.A., Kubatiev A.A., Khasanova G.R., Yakovlev M.Yu. Endotoxin is a component in the pathogenesis of chronic viral diseases // Human Physiology. 2015. V. 41. № 3. P. 328.
  20. Khasanova G.R., Bikkinina O.I., Anokhin V.A. et al. [Intestinal factor in HIV progression infections] // Uspehi Sovr. Biol. 2020. V. 140. № 3. P. 278.
  21. Yatskov I.A., Beloglazov V.A., Kubyshkin A.V. et al. The influence of antibiotic therapy on indicators of endotoxinemia and systemic inflammation in acute SARS-CoV-2 lung damage // Acta Biomed. Sci. 2022. V. 7. № 1. P. 12.
  22. Markelova M.M., Ryumina I.I., Salakhov I.M., Yakovlev M.Yu. [Systemic endotoxemia and fat metabolism in newborns: a cross-sectional study] // Patol. Fiziol. Eksp. Ter. (Pathol. Physiol. Exp. Ther.). 2017. V. 61. № 3. P. 91.
  23. Yakovlev M.Yu. Elements of the endotoxin theory of human physiology and pathology // Human Physiology. 2003. V. 29. № 4. P. 476.
  24. Meshkov M.V., Anikhovskaya I.A., Yakovleva M.M., Yakovlev M.Yu. Intestinal endotoxin in regulation of hemostasis activity and in pathogenesis of the DIC syndrome // Human Physiology. 2005. V. 31. № 6. P. 700.
  25. Foster J.A., Lyte M., Meyer E., Cryan J.F. Gut Microbiota and Brain Function: An Evolving Field in Neuroscience // Int. J. Neuropsychopharmacol. 2016. V. 19. № 5. P. pyv114.
  26. Anikhovskaya I.A., Dvoenosov V.G., Zhdanov R.I. et al. [Psycho-emotional stress as a clinical model of the initial phase of the general adaptation syndrome] // Patol. Fiziol. Eksp. Ter. (Pathol. Physiol. Exp. Ther.). 2015. V. 59. № 4. P. 87.
  27. Abdul-Aziz M.A., Cooper A., Weyrich L.S. Exploring relationships between host genome and microbiome: new insights from genome-wide association studies // Front. Microbiol. 2016. V. 7. P. 1611.
  28. Cani P.D., Amar J., Iglesias M.A. et al. metabolic endotoxemia initiates obesity and insulin resistance // Diabetes. 2007. V. 56. № 7. P. 1761.
  29. Cani P.D., Bibiloni R., Knauf C. et al. Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fatdiet-induced obesity and diabetes in mice // Diabetes. 2008. V. 57. № 6. P. 1470.
  30. Okorokov P.L., Anikhovskaya I.A., Volkov I.E. et al. Intestinal endotoxin as a trigger of type 1 diabetes mellitus // Human Physiology. 2011. V. 37. № 2. P. 247.
  31. Gordienko A.I., Beloglazov V.N., Kubyshkin A.V. [Imbalance of humoral anti-endotoxin immunity and low-intensity inflammation in diabetes mellitus types 1 and 2] // Patol. Fiziol. Eksp. Ter. (Pathol. Physiol. Exp. Ther.). 2016. V. 60. № 3. P. 61.
  32. Kotrova A.D., Shishkin A.N., Ermolenko E.I. et al. [Gut microbiota and hypertension] // Arterial’naya Gipertenziya (Arterial Hypertension). 2020. V. 26. № 6. P. 620.
  33. Cani P.D. Human gut microbiome: Hopes, threats and promises // Gut. 2018. V. 67. № 9. P. 1716.
  34. Beloglazov V.A., Yatskov I.A., Kumelsky E.D., Polovinkina V.V. Metabolic endotoxinemia: possible causes and consequences // Obesity and Metabolism. 2021. V. 18. № 3. P. 320.
  35. Yakovlev M.Yu. [Intestinal endotoxin and inflammation] / Dermatology. National leadership. Brief edition. Мoscow: GEOTAR-Media, 2013. Chapter 8. P. 70.
  36. Anikhovskaya I.A., Kubatiev A.A., Yakovlev M.Yu. Endotoxin theory of aterosclerosis // Human Physiology. 2015. V. 41. № 1. P. 89.
  37. Pokusaeva D.P., Anikhovskaya I.A., Korobkova L.A. et al. [Correlations of indices of systemic endotoxinemia with lipid profile in patients without clinical manifestation of atherosclerosis] // Patogenez (Pathogenesis). 2018. V. 16. № 4. P. 182.
  38. Pokusaeva D.P., Anikhovskaya I.A., Korobkova L.A. еt al. Prognostic importance of systemic endotoxinemia indicators in atherogenesis // Human Physiology. 2019. V. 45. № 5. P. 543.
  39. Ryabov V.V., Kretov E.I., Popov S.V. et al. Technology of coronary stenting and the role of inflammation in atherogenesis: problems and prospects // Bull. Sib. Med. 2021. V. 20. № 1. P. 200.
  40. Anikhovskaya I.A., Golyshev I.S., Tebloev K.I., Yakovlev M.Yu. The role of endotoxin agression in pathogenesis of acute myocardial infarction // Human Physiology. 2014. V. 40. № 3. P. 348.
  41. Gordienko A.I., Beloglazov V.A., Kubyshkin A.V. et al. Humoral anti-endotoxin immunity imbalance as a probable factor in the pathogenesis of autoimmune diseases // Human Physiology. 2019. V. 45. № 3. P. 337.
  42. Gordienko A.I., Beloglazov V.A., Anikhovskaya I.A. et al. Activity of humoral antiendotoxin immunity is associated with low-intensity inflammation and oxidative stress in ankylosing spondylitis: endotoxin component of disease pathogenesis // Human Physiology. 2022. V. 48. № 5. P. 577.
  43. Anokhin V.A., Bulatova G.R., Krupnik A.N., Yakov-lev M.Yu. [Systemic endotoxinemia and broncho-obstructive syndrome in acute respiratory viral infection in children] // Kazan Med. J. 1992. V. 73. № 2. P. 8.
  44. Sozinov A.S. Systemic endotoxinemia during chronic viral hepatitis // Bull. Exp. Biol. Med. 2002. V. 133. № 2. P. 183.
  45. Sozinov A.S., Anikhovskaya I.A., Enaleeva D.S. et al. Functional activity of endotoxin binding factors in chronic viral hepatitis B and C // J. Microbiol. Epidemiol. Immunol. 2001. № 6. P. 56.
  46. Shmoilov D.K., Karimov I.Z. [Activity of the humoral component of anti-endotoxin immunity in patients with influenza A] // Patogenez (Pathogenesis). 2020. V. 18. № 1. P. 51.
  47. Vyshegurov Y.Kh., Anikhovskaya I.A., Batma- nov Yu.E., Yakovlev M.Yu. Intestinal endotoxin in the pathogenesis of inflammatory eye pathology and the antiendotoxin component of treatment // Patol. Fiziol. Eksp. Ter. (Pathol. Physiol. Exp. Ther.). 2007. № 1. P. 12.
  48. Vyshegurov Ya.Kh., Anikhovskaya I.A., Rascheskov A.Yu. et al. Etiology of endotoxin agression and its role as an obligate pathogenetic factor in iridocyclites of different origins // Human Physiology. 2006. V. 32. № 6. P. 726.
  49. Bander Z.A., Nitert M.D., Mousa A., Naderpoor N. The gut microbiota and inflammation: An overview // Int. J. Environ. Res. Public Health. 2020. V. 17. № 20. P. 7618.
  50. Sun P., Su L., Zhu H. et al. Gut microbiota regulation and their implication in the development of neurodegenerative disease // Microorganisms. 2021. V. 9. № 11. P. 2281.
  51. Toledo L., Monroy G., Salazar F., Lee J. Gut–brain axis as a pathological and therapeutic target for neurodegenerative disorders // Int. J. Mol. Sci. 2022. V. 23. № 3. P. 1184.
  52. Zozulya S.A., Otman I.N., Yunilaynen O.A. et al. [Markers of systemic inflammation and systemic endotoxinemia in patients with acute endogenous psychoses] // Patogenez (Pathogenesis). 2020. V. 18. № 1. P. 34.
  53. Zozulya S.A., Yakovlev M.Yu., Klyushnik T.P. [Gut microbiota and (neuro)inflammation: involvement of endotoxin in the pathogenesis of endogenous psychoses] // Psikhiatriya. 2023. V. 21. № 5. P. 86.
  54. Enukidze G.G., Anikhovskaya I.A., Marachev A.A., Yakovlev M.Yu. Antiendotoxin direction in thetreatment of chronic inflammation and female infertility / Novye lechebno-diagnosticheskie tekhnologii (New Diagnostic and Treatment Technologies). Moscow: KDO-test, 2007. V. 3. 78 р.
  55. Manukhin I.B., Kraposhina T.P., Kerimova S.P. [Endotoxemia and antiendotoxin immunity in patients with anembryonic pregnancies in the first trimester] // Russ. Bull. Obstet.-Gynecol. 2019. V. 19. № 3. P. 17.
  56. Meshkov M.V., Anikhovkaya I.A., Gataullin Yu.K., Yakovlev M.Yu. [Endotoxin aggression as a universal factor of pathogenesis of hemostasis disorders in children with urological pathology] // Urology. 2006. № 1. P. 15.
  57. Meshkov M.V., Gataullin Yu.K., Ivanov V.B., Yakovlev M.Yu. Endotoxin aggression as a cause of postoperative complications in pediatric surgery / New therapeutic and diagnostic technologies. Moscow: KDO-Test, 2007. V. 2. 142 р.
  58. Medzhitov R., Janevey Ch. [Innate immunity] // Kazan Med. J. 2004. V. 85. № 3. P. 161.
  59. Yakovlev M.Yu. [Intestinal endotoxin: immunity — inflammation — aging as links in one chain] // Patogenez (Pathogenesis). 2020. V. 18. № 1. P. 82.
  60. Anikhovskaya I.A., Salakhov I.M., Yakovlev M.Yu. Intestinal endotoxin and stress in adaptation and aging // Bull. Russ. Acad. Nat. Sci. 2016. V. 16. № 1. P. 19.
  61. Manzel A., Muller D.N., Haflr D.A. et al. Role of "Western diet" in inflmmatory autoimmune diseases // Curr. Allergy Asthma Rep. 2014. V. 14. № 1. P. 404.
  62. Timmermans S., Bogie J.F., Vanmierlo T. et al. High fat diet exacerbates neuroinflmmation in an animal model of multiple sclerosis by activation of the Renin Angiotensinsystem // J. Neuroimmune Pharmacol. 2014. V. 9. № 2. P. 209.
  63. Hanna Kazazian N., Wang Y., Roussel-Queval A. et al. Lupus autoimmunity and metabolic parameters are exacerbated on high fat diet-induced obesity due to TLR7 signaling // Front. Immunol. 2019. V. 10. P. 2015.
  64. Chehimi M., Vidal H., Eljaafari A. Pathogenic role of IL-17-producingimmune cells in obesity, and related inflmmatory diseases // J. Clin. Med. 2017. V. 6. № 7. P. 68.
  65. Lassenius M.I., Pietilainen K.H., Kaartinen K. et al. Bacterial endotoxinactivity in human serum is associated with dyslipidemia, insulinresistance, obesity, and chronic inflammation // Diabetes Care. 2011. V. 34. № 8. P. 1809.
  66. Savelyev V.S., Petukhov V.A., Karalkin A.V. et al. Intestinal failure syndrome in urgent abdominal surgery: new methodological approaches to treatment // Difficult Patient. 2005. V. 3. № 4. P. 30.
  67. Needham B.D., Kaddurah-Daouk R., Mazmanian S.K. Gut microbial molecules in behavioural and neurodegenerative conditions // Nat. Rev. Neurosci. 2020. V. 21. № 12. P. 717.
  68. Sgritta M., Dooling S.W., Buffington S.A. et al. Mechanisms underlying microbial-mediated changes in social behavior in mouse models of autism spectrum disorder // Neuron. 2019. V. 101. № 2. P. 246.
  69. Zhao J., Bi W., Xiao S. et al. Neuroinflammation induced by lipopolysaccharide causes cognitive impairment in mice // Sci. Rep. 2019. V. 9. № 1. P. 5790.
  70. Izvolskaia M., Sharova V., Zakharov L. Prenatal programming of neuroendocrine system development by lipopolysaccharide: long-term effects // Int. J. Mol. Sci. 2018. V. 19. № 11. P. 3695.
  71. Parker A., Fonseca S., Carding S.R. Gut microbes and metabolites as modulators of blood-brain barrier integrity and brain health // Gut Microbes. 2020. V. 11. № 2. P. 135.
  72. Sherwin E., Bordenstein S.R., Quinn J.L. et al. Microbiota and the social brain // Science. 2019. V. 366. № 6465. P. eaar2016.
  73. Speransky A.D. [Elements of constructing a theory of medicine]. M.-L.: Publishing House of the All-Union Institute of Experimental Medicine, 1935. 344 p.
  74. Rascheskov А.А., Markelova М.М., Anikhovskaya I.A. et al. [Determination of the endotoxin aggression etiology as a prospect for improving the effectiveness of the treatment-and-prophylactic process] // Kazan Med. J. 2022. V. 103. № 3. P. 467.
  75. Tan L.Y., Yeo X.Y., Bae H.G. et al. Association of gut microbiome dysbiosis with neurodegeneration: Can gut microbe-modifying diet prevent or alleviate the symptoms of neurodegenerative diseases? // Life (Basel). 2021. V. 11. № 7. P. 698.
  76. Athari Nik Azm S., Djazayeri A., Safa M. et al. Lactobacilli and bifidobacteria ameliorate memory and learning deficits and oxidative stress in beta-amyloid (1-42) injected rats // Appl. Physiol. Nutr. Metab. 2018. V. 43. № 7. P. 718.
  77. Mohammadi G., Dargahi L., Naserpour T. et al. Probiotic mixture of Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 attenuates hippocampal apoptosis induced by lipopolysaccharide in rats // Int. Microbiol. 2019. V. 22. № 3. P. 317.
  78. Magaeva S.V., Morozov S.G. [Neuroimmunophysiology]. Moscow: Publishing house of the State Research Institute of Biomed. Chemistry named after V.N. Orekhovich RAMS, 2005. 160 p.
  79. Morozov S.G., Lobanov A.V., Kozhevnikova E.N. et al. [Perinatal neuroimmunopathology: from experiment to clinic] // Patogenez (Pathogenesis). 2022. V. 20. № 3. P. 24.
  80. Papysheva O.V., Morozov S.G., Gribova I.E. et al. [Long-term neurological consequences in children born to mothers with gestational diabetes mellitus] // Vopr. Prakt. Pediatr. (Clinical Practice in Pediatrics). 2022. V. 17. № 2. P. 23.
  81. Likhoded V.G., Anikhovskaya I.A., Salakhov I.M. et al. Fc-receptor-mediated binding of lipopolysaccharides by human leukocytes in physiology and pathology // J. Endotoxin Res. 2000. V. 6. № 2. P. 24.
  82. Huang X., Fend Y., Xiong G. et al. Caspase-11, a specific sensor for entracellular lipopolysaccharide recognition mediates the non-canonical inflammation pathway of pyroptosis // Cell Biosci. V. 9. P. 31.
  83. Franceschi C., Bonafè M., Valensin S. et al. Inflamm-aging. An evolutionary perspective on immunosenescence // Ann. N.Y. Acad. Sci. 2000. V. 908. P. 244.
  84. Franceschi C., Garagnani P., Vitale G. et al. Inflmmaging and ‘Garb-aging’ // Trends Endocrinol. Metab. 2017. V. 28. № 3. P. 199.
  85. Chernikhova E.A., Anikhovskaya I.A., GataullinYu. K. et al. Enterosorbtion as an approoach to the elimination of chronic endotoxin aggression // Human Physiology. 2007. V. 33. № 3. P. 373.
  86. Gordienko A.I., Khimich N.V., Beloglazov V.I. et al. Polyreactive transformation of class G immunoglobulins as a vector for search of potential means for improving the activity of anti-endotoxin immunity // Human Physiology. 2020. V. 46. № 5. P. 554.

Arquivos suplementares

Arquivos suplementares
Ação
1. JATS XML
Baixar
2. Fig. 1. The family of TOL-like receptors, their ligands and signaling pathways (according to [6] in the author’s modification).

Baixar (532KB)
Metadados
3. Fig. 2. Under conditions of systemic endotoxinemia (A), the immune status is balanced; under conditions of endotoxin aggression (B), the pro-inflammatory status predominates, since it is not balanced by the anti-inflammatory action of the adrenal cortex (according to [35] in the author’s modification).

Baixar (489KB)
Metadados
4. Fig. 3. Percentage (A) and number of bacteria (B) forming endotoxin aggression (according to [74] in the author’s modification).

Baixar (318KB)
Metadados
5. Fig. 4. The periodicity of the systemic inflammatory response syndrome (SIRS) in HIV infection, when the phase of LPS-induced hyperactivation of the immune system is replaced by its exhaustion, is associated with the cycles of viral replication and the resulting damage to the intestinal barrier (according to [19] in the author’s modification).

Baixar (123KB)
Metadados
6. Fig. 5. Age-related changes in integral indicators of systemic endotoxinemia are characterized by an increase in the level of LPS in the blood, a decrease in integral indicators of the activity of the humoral link of antiendotoxin immunity and the body's ability to increase body temperature (according to [7] in the author's modification).

Baixar (365KB)
Metadados
7. Fig. 6. The universal role of endotoxin aggression of general pathology is in the induction of systemic inflammation (according to [7] in the author’s modification).

Baixar (648KB)
Metadados

Declaração de direitos autorais © Russian Academy of Sciences, 2024