Comparative Determination of Immunological Indicators for Assessment of Phantom Pain

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A comparative determination of immunological parameters, natural antibodies (e-Abs) to the regulators of the main systems of biochemical homeostasis was carried out: β-endorphin, serotonin, dopamine, histamine, orphanin, angiotensin, GABA, glutamate, bradykinin, vasopressin, thrombin, α2-macroglobulin in persons with phantom pain syndrome (PPS) resulting from amputation after injury. In accordance with the established diagnosis, a group of 14 people was examined, for whom features of the distribution of immunological parameters were identified. For each examined patient, an individual immunoprofile of specific e-Abs was determined. A significant increase in the level of antibodies to serotonin, histamine and angiotensin was established for all study participants, reflecting the degree of manifestation of FBS, which does not depend on the self-esteem of the person being examined. Determining the role of regulators of biochemical homeostasis in the development of phantom pain showed that with high, moderate and weak severity of FBS, the biogenic amine and angiotensinergic systems are activated. A decrease in FBS intensity normalizes deviations in all immunological parameters. The level of e-Abs for the pain (β-endorphin) and analgesic (orphanin) systems are significant only at low FBS. Monitoring the individual profile of e-Abs to endogenous regulators allows us to obtain an objective picture of the pain status of the patient’s body. The severity of pain, assessed on various scales, may have no connection with the degree of imbalance of these systems, with neurophysiological and other characteristics of the manifestation of pain.

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作者简介

M. Myagkova

Institute of Physiologically Active Substances Federal Research Center for Problems of Chemical Physics and Medical Chemistry RAS

Email: dianark777@mail.ru
俄罗斯联邦, Chernogolovka, Moscow region

Z. Bobrova

Institute of Physiologically Active Substances Federal Research Center for Problems of Chemical Physics and Medical Chemistry RAS

Email: dianark777@mail.ru
俄罗斯联邦, Chernogolovka, Moscow region

S. Petrochenko

Institute of Physiologically Active Substances Federal Research Center for Problems of Chemical Physics and Medical Chemistry RAS

编辑信件的主要联系方式.
Email: dianark777@mail.ru
俄罗斯联邦, Chernogolovka, Moscow region

A. Krylov

DIANARK LLC

Email: dianark777@mail.ru
俄罗斯联邦, Moscow

I. Moseykin

Russian Medical Academy of Postgraduate Education

Email: dianark777@mail.ru
俄罗斯联邦, Moscow

参考

  1. Osipova N.A., Sobchenko L.A. [Post amputation phantom pain syndrome medical and social problems] // Anesteziol. Reanimatol. 2011. № 6. P. 41.
  2. Jackson M.A., Simpson K.H. Pain after amputation / Continuing Education in Anaesthesia Critical Care & Pain // Br. J. Anaesth. 2004. V. 4. № 1. Р. 20.
  3. Hsiao A.F., York R., Hsiao I. et al. A randomized controlled study to evaluate the efficacy of noninvasive limb cover for chronic phantom limb pain among veteran amputees // Arch. Phys. Med. Rehabil. 2012. V. 93. № 4. P. 617.
  4. Rusanescu G., Mao J. Immature spinal cord neurons are dynamic regulators of adult nociceptive sensitivity // J. Cell. Mol. Med. 2015. V. 19. № 10. P. 2352.
  5. Moura V.L., Faurot K.R., Gaylord S.A. et al. Mind-body interventions for treatment of phantom limb pain in persons with amputation // Am. J. Phys. Med. Rehabil. 2012. V. 91. № 8. P. 701.
  6. Attal N., Bouhassira D., Baron R. Diagnosis and assessment of neuropathic pain through questionnaires // Lancet Neurol. 2018. V. 17. № 5. P. 456.
  7. Myagkova M.A., Petrochenko S.N., Morozova V.S. Detection of natural antibodies to endogenous bioregulators for the diagnostics of the functional state of the body // Rus. Chem. Bull. 2018. V. 67. № 4. P. 762.
  8. Verma V., Sheikh Z., Ahmed A.S. Nociception and role of immune system in pain // Acta Neurol. Belg. 2015. V. 115. № 3. P. 213.
  9. Reshetnyak V.K., Kukushkin M.L. [Central and peripheral mechanisms of physiologic and pathologic pain] // Clin. Pathophysiol. 2015. № 1. P. 1.
  10. Levashova A.I., Morozova V.S., Petrochenko S.N. et al. [A comparative study of immune and clinical indicators in radicular and myofascial back pain] // Zh. Nevrol. Psikhiatr. Im. S.S. Korsakova. 2017. V. 117. № 3. P. 4.
  11. Levashova A.I., Myagkova M.A. Analysis of immunochemical parameters in vertebrogenic pain syndrome // Biomed. Chem. Res. Methods. 2018. V. 1. № 3. P. e00039.
  12. Igonkina S.I., Vetrilae L.A., Zakharova I.A., Kukushkin M.L. [Antibodies to neurotransmitters in neuropathic pain] // Neuroimmunol. 2015. V. 12. № 1–2. P. 45.
  13. Igonkina S.I., Vetrilae L.A., Kukushkin M.L. [Influence of antibodies to noradrenaline on the development of neuropathic pain] // Bull. Exp. Biol. Med. 2016. V. 162. № 12. P. 678.
  14. Petrochenko S.N., Bobrova Z.V., Myagkova M.A. [The detection of antibodies to endogenous bio-regulators for evaluating functional condition of health of sportsmen] // Klin. Lab. Diagn. 2017. V. 62. № 2. P. 346.
  15. Obara I., Telezhkin V., Alrashdi I., Chazot P.L. Histamine, histamine receptors, and neuropathic pain relief // Br. J. Pharmacol. 2019. V. 177. № 3. P. 580.
  16. Manjulo I.V., Duisen I.V. [Neurochemical changes in the rostral ventromedial nucleus of the rat medulla oblongata during the development of neuropathic pain syndrome] // Neurochemistry. 2015. № 3. P. 259.
  17. Ahmed M.A., Mohamed S.A., Sayed D. Long-term antalgic effects of repetitive transcranial magnetic stimulation of motor cortex and serum beta-endorphin in patients with phantom pain // Neurol. Res. 2011. V. 33. № 9. P. 953.
  18. Levashova A.I., Myagkova M.A., Moseikin I.A. [Immunochemical and electromyographic indicators for assessment of pain status in myofascial back pain syndrome] // Zh. Nevrol. Psikhiatr. im. S.S. Korsakova. 2020. V. 120. № 12. P. 73.
  19. Walker A.K., Kavelaars A., Heijnen C.J., Dantzer R. Neuroinflammation and comorbidity of pain and depression // Pharmacol. Rev. 2014. V. 66. № 1. P. 80.
  20. Viana F. TRPA1 channels: molecular sentinels of cellular stress and tissue damage // J. Physiol. 2016. V. 594. № 15. P. 4151.
  21. Toll L., Bruchas M.R., Calo' G. et al. Nociceptin/orphanin FQ receptor structure, signaling, ligands, functions, and interactions with opioid systems // Pharmacol. Rev. 2016. V. 68. № 2. P. 419.
  22. Levashova A.I., Myagkova M.A. Mechanism of action of anti-opioid peptides at pain syndrome // Rus. Chem. Bull. 2018. V. 67. № 4. P. 624.
  23. Nuss P. Anxiety disorders and GABA neurotransmission: a disturbance of modulation // Neuropsychiatr. Dis. Treat. 2015. V. 11. P. 165.
  24. Davydova T.V., Kolobov V.V., Gorbatov V.Yu. et al. [Glutamate antidodies, brain neurodegenerative damages. Perspectives of immunotherapy] // Pathogenesis. 2012. V. 10. № 3. P. 26.
  25. Gordeev A.V., Galushko E.A., Savushkina N.M. [The role of the angiotensins in the pathogenesis of inflammatory joint disease] // Ter. Arkh. 2021. V. 93. № 5. P. 635.
  26. Williams F.M., Scollen S., Cao D. et al. Genes contributing to pain sensitivity in the normal population: an exome sequencing study // PLoS Genet. 2012. V. 12. № 8. Р. e1003095.
  27. Dutra R.C., Bento A.F., Leite D.F. et al. The role of kinin B1 and B2 receptors in the persistent pain induced by experimental autoimmune encephalomyelitis (EAE) in mice: Evidence for the involvement of astrocytes // Neurobiol. Dis. 2013. V. 54. P. 82.

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