Copper(II) 2-(N-tosylamino)benzaldehyde benzoylhydrazone complexes: synthesis, structures, properties, and biological activity

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Resumo

A number of new copper(II) complexes of 2-(N-tosylamino)benzaldehyde benzoylhydrazone (H2L) CuLLn (n = 1–6) with heterocyclic donor ligands (L1 = 1-propyl-2-aminobenzimidazole, L2 = 1-hexyl-2-aminobenzimidazole, L3 = 1-octyl-2-aminobenzimidazole, L4 = 2,2΄-bipyridine, L5 = 1,10-phenanthroline, and L6 = 2-aminopyridine) is synthesized. The structures and compositions of the synthesized compounds are determined by elemental analysis, 1Н NMR spectroscopy, IR spectroscopy, and magnetochemistry. The molecular structures of complexes CuLL1,2,4–6 are determined by XRD (CIF files CCDC nos. 2341480 (CuLL1), 2341468 (CuLL2), 2341478 (CuLL4), 2341477 (CuLL5), and 2341479 (CuLL6)). The biological activity of the complexes is studied. The adducts with L1, L2, and L6 exhibit a significantly higher anti-protist activity than chloroquine used as the reference compound.

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Sobre autores

B. Chal’tsev

Southern Federal University

Email: anatoly.burlov@yandex.ru

Research Institute of Physical and Organic Chemistry

Rússia, Rostov-on-Don

A. Burlov

Southern Federal University

Autor responsável pela correspondência
Email: anatoly.burlov@yandex.ru

Research Institute of Physical and Organic Chemistry

Rússia, Rostov-on-Don

V. Vlasenko

Southern Federal University

Email: anatoly.burlov@yandex.ru

Research Institute of Physics

Rússia, Rostov-on-Don

Yu. Koshchienko

Southern Federal University

Email: anatoly.burlov@yandex.ru

Research Institute of Physical and Organic Chemistry

Rússia, Rostov-on-Don

A. Zubenko

North-Caucasian Zonal Scientific Research Veterinary Institute - Branch of the Federal State Budget Scientific Institution “Federal Rostov Agricultural Research Centre”

Email: anatoly.burlov@yandex.ru
Rússia, Novocherkassk

A. Klimenko

North-Caucasian Zonal Scientific Research Veterinary Institute - Branch of the Federal State Budget Scientific Institution “Federal Rostov Agricultural Research Centre”

Email: anatoly.burlov@yandex.ru
Rússia, Novocherkassk

V. Lazarenko

National Research Center Kurchatov Institute

Email: anatoly.burlov@yandex.ru
Rússia, Moscow

S. Mashchenko

Southern Federal University

Email: anatoly.burlov@yandex.ru

Research Institute of Physical and Organic Chemistry

Rússia, Rostov-on-Don

E. Korshunova

Southern Federal University

Email: anatoly.burlov@yandex.ru

Research Institute of Physical and Organic Chemistry

Rússia, Rostov-on-Don

T. Lifintseva

Southern Federal University

Email: anatoly.burlov@yandex.ru
Rússia, Rostov-on-Don

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2. Sc.1. Synthesis of CuLL1-6 complexes.

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3. Fig. 1. Molecular structure of CuLL1. Dotted lines show intra- and intermolecular hydrogen bonds.

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4. Fig. 2. Molecular structure of CuLL2.

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5. Fig. 3. Molecular structure of CuLL4.

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6. Fig. 4. Molecular structure of CuLL5.

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7. Fig. 5. Molecular structure of CuLL6.

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8. Fig. 6. π-π interactions in CuLL4.

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