Molecular-genetic markers of neuroglia in traumatic brain injury and their use for assessing functional status of sportsmen

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Abstract

Neuroglia performs multiple important functions including maintaining brain homeostasis, metabolism, neuroprotection and modulating neurotransmission. Studying the role of neuroglia is necessary to understand the development of pathological neurodegenerative processes, as well as the restoration of nervous tissue during inflammation or injury. However, the analysis of neuroglial processes is complicated by its high heterogeneity and the lack of a system of biomarkers that make it possible to unambiguously assess the functional state of the nervous system. Here, we analyze data on clinically significant molecular genetic markers of different types of neuroglia, and the prospects for their use in sport physiology, including the assessment of athletes following traumatic brain injuries of varying severity and other types of sport-related traumas.

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About the authors

А. V. Cherepanova

Sirius University of Science and Technology

Author for correspondence.
Email: anesthesia.cher@gmail.com
Russian Federation, Sirius Federal Territory

Y. R. Bravy

Sirius University of Science and Technology

Email: anesthesia.cher@gmail.com
Russian Federation, Sirius Federal Territory

A. V. Karabelsky

Sirius University of Science and Technology

Email: anesthesia.cher@gmail.com
Russian Federation, Sirius Federal Territory

М. M. Kotova

Sirius University of Science and Technology

Email: anesthesia.cher@gmail.com
Russian Federation, Sirius Federal Territory

A. S. Sherbakova

Kuban State Agrarian University named after I. T. Trubilin

Email: anesthesia.cher@gmail.com
Russian Federation, Krasnodar

К. V. Apukhtin

Sirius University of Science and Technology

Email: anesthesia.cher@gmail.com
Russian Federation, Sirius Federal Territory

V. S. Nikitin

Sirius University of Science and Technology

Email: anesthesia.cher@gmail.com
Russian Federation, Sirius Federal Territory

М. Yu. Bobrov

Sirius University of Science and Technology

Email: anesthesia.cher@gmail.com
Russian Federation, Sirius Federal Territory

A. V. Kalueff

Sirius University of Science and Technology; St. Petersburg State University

Email: anesthesia.cher@gmail.com

Institute of Translational Biomedicine

Russian Federation, Sirius Federal Territory; St. Petersburg

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2. Fig. 1. Physiological role and molecular markers of neurons and glial cells (see also Table 1).

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3. Fig. 2. Changes in the functional activity of glial cells in traumatic brain injury.

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