Effect of Low Molecular Weight Nerve Growth Factor Mimetic GK-2 on Cognitive Function and Synaptic Transmission in Hippocampal Slices

A. A. Volkova; Волкова А. А.; P. Yu. Povarnina; Поварнина П. Ю.; P. D. Rogozin; Рогозин П. Д.; R. V. Kondratenko; Кондратенко Р. В.; I. N. Sharonova; Шаронова И. Н.; A. A. Kamensky; Каменский А. А.; V. G. Skrebitsky; Скребицкий В. Г.

doi:10.31857/S1027813323020188

Effect of Low Molecular Weight Nerve Growth Factor Mimetic GK-2 on Cognitive Function and Synaptic Transmission in Hippocampal Slices

Autores: Volkova A.A.¹^,2, Povarnina P.Y.¹, Rogozin P.D.³, Kondratenko R.V.³, Sharonova I.N.³, Kamensky A.A.², Skrebitsky V.G.³
Afiliações:
1. Research Zakusov Institute of Pharmacology
2. Lomonosov Moscow State University, Faculty of Biology
3. Research Center of Neurology
Edição: Volume 40, Nº 2 (2023)
Páginas: 166-171
Seção: Experimental Articles
URL: https://cardiosomatics.ru/1027-8133/article/view/653947
DOI: https://doi.org/10.31857/S1027813323020188
EDN: https://elibrary.ru/UDDMTT
ID: 653947

Citar

Texto integral

Acesso aberto
Acesso é fechado

Acesso está concedido
Acesso é fechado

Acesso é pago ou somente para assinantes

Resumo
Sobre autores
Bibliografia
Arquivos suplementares
Estatísticas

Resumo

Nerve growth factor (NGF) contributes to the proliferation, differentiation and maintenance of the viability and functioning of peripheral and central neurons. At the Research Zakusov Institute of Pharmacology a dimeric dipeptide mimetic of the NGF loop 4 bis(monosuccinyl-L-glutamyl-L-lysine) hexamethylenediamide (GK-2) was created. GK-2 activates PI3K/AKT and PLC-γ1 signaling cascades, without affecting MAPK/ERK, and appears to have procognitive properties. In the present study, we investigated the mnemotropic effects of GK-2 with a single intraperitoneal dose of 0.1, 0.5 and 5.0 mg/kg in the novel object recognition test in rats. GK-2 at a dose of 0.5 mg/kg statistically significantly improved the long-term memory of animals. In experiments on the rat hippocampal acute slices, we evaluated the effects of GK-2 on synaptic transmission and its plastic properties in the synaptic system Schaffer collaterals − CA1 pyramidal cell.

Palavras-chave

hippocampal slices, PPR, low molecular weight NGF mimetic, novel object recognition test

Bibliografia

Skaper S.D. // Methods Mol. Biol. 2012. V. 846. P. 1–12.
Aloe L., Rocco M.L., Bianchi P., Manni L. // J. Transl. Med. 2012. V. 10. № 1. P. 239.
Ivanov A.D., Tukhbatova G.R., Salozhin S.V., Markevich V.A. // Neuroscience. 2015. V. 289. P. 114–122.
Dobryakova Y.V., Spivak Y.S., Zaichenko M.I., Koryagina A.A., Markevich V.A., Stepanichev M.Y., Bolshakov A.P. // Front. Neurosci. 2021. V. 15.
Xu C.-J., Wang J.-L., Jin W.-L. // Neurochem. Res. 2016. V. 41. № 6. P. 1211–1218.
Manni L., Conti G., Chiaretti A., Soligo M. // Front. Pharmacol. 2021. V. 12.
Allen S.J., Watson J.J., Shoemark D.K., Barua N.U., Patel N.K. // Pharmacol. Ther. 2013. V. 138. № 2. P. 155–175.
Xie Y., Tisi M.A., Yeo T.T., Longo F.M. // J. Biol. Chem. 2000. V. 275. № 38. P. 29868–29874.
Scarpi D., Cirelli D., Matrone C., Castronovo G., Rosini P., Occhiato E.G., Romano F., Bartali L., Clemente A.M., Bottegoni G., Cavalli A., De Chiara G., Bonini P., Calissano P., Palamara A.T., Garaci E., Torcia M.G., Guarna A., Cozzolino F. // Cell Death Dis. 2012. V. 3. № 7. P. e339–e339.
Jain P., Li R., Lama T., Saragovi H.U., Cumberlidge G., Meerovitch K. // Exp. Eye Res. 2011. V. 93. № 4. P. 503–512.
Гудашева Т.А., Антипова Т.А., Середенин С.Б. // Доклады Академии наук. 2010. Т. 434. № 4. С. 549–552.
Gudasheva T.A., Povarnina P.Y., Antipova T.A., Firsova Y.N., Konstantinopolsky M.A., Seredenin S.B. // J. Biomed. Sci. 2015. V. 22. № 1. P. 106.
Gudasheva T.A., Logvinov I.O., Nikolaev S.V., Antipova T.A., Povarnina P.Y., Seredenin S.B. // Dokl. Biochem. Biophys. 2020. V. 494. № 1. P. 244–247.
Антипова Т.А., Николаев С.В., Гудашева Т.А. // Экспериментальная и клиническая фармакология. 2014. Т. 77. № 2. С. 8–11.
Povarnina P.Y., Vorontsova O.N., Gudasheva T.A., Ostrovskaya R.U., Seredenin S.B. // Acta Naturae. 2013. V. 5. № 3. P. 84–91.
Волкова А.А., Поварнина П.Ю., Гудашева Т.А., Середенин С.Б. // Химико-фармацевтический журнал. 2022. Т. 56. № 4. С. 3–6.
Collingridge G.L., Isaac J.T.R., Wang Y.T. // Nat. Rev. Neurosci. 2004. V. 5. № 12. P. 952–962.
Milner B., Squire L.R., Kandel E.R. // Neuron. 1998. V. 20. № 3. P. 445–468.
Середенин С.Б., Гудашева Т.А. // Журнал неврологии и психиатрии им. С.С. Корсакова. 2015. № 6. С. 63–70.
Gudasheva T.A., Povarnina P., Logvinov I.O., Antipova T.A., Seredenin S.B. // Drug Des. Devel. Ther. 2016. V. 10. P. 3545–3553.
Ennaceur A., Delacour J. // Behav. Brain Res. 1988. V. 31. № 1. P. 47–59.
Antunes M., Biala G. // Cogn. Process. 2011. V. 13. № 2. P. 93–110.
Beldjoud H., Barsegyan A., Roozendaal B. // Front. Behav. Neurosci. 2015. V. 9. P. 108.
Puzzo D., Privitera L., Palmeri A. // Neurobiol. Aging. 2012. V. 33. № 7. P. 1484.e15–1484.e24.
Calabrese E. // Int. J. Mol. Sci. 2018. V. 19. № 10. P. 2871.
Calabrese E.J. // Br. J. Clin. Pharmacol. 2008. V. 66. № 5. P. 594–617.
Поварнина П.Ю., Гудашева Т.А., Воронцова О.Н., Бондаренко Н.А., Середенин С.Б. // Бюллетень экспериментальной биологии и медицины. 2011. Т. 151. № 6. С. 634–637.
Иванов С.В., Островская Р.У., Гудашева Т.А., Середенин С.Б. // Химико-фармацевтический журнал. 2021. Т. 55. № 4. С. 11–15.
Kemp S.W.P., Webb A.A., Dhaliwal S., Syed S., Walsh S.K., Midha R. // Exp. Neurol. 2011. V. 229. № 2. P. 460–470.
Wang X., Bauer J.H., Li Y., Shao Z., Zetoune F.S., Cattaneo E., Vincenz C. // J. Biol. Chem. 2001. V. 276. № 36. P. 33812–33820.
Stelmashook E.V., Aleksandrova O.P., Rogozin P.D., Genrikhs E.E., Novikova S.V., Gudasheva T.A., Sharo-nova I.N., Skrebitsky V.G., Isaev N.K. // Bull. Exp. Biol. Med. 2020. V. 168. № 4. P. 474–478.
Regehr W.G. // Cold Spring Harb. Perspect. Biol. 2012. V. 4. № 7. P. a005702–a005702.
Kang H., Schuman E. // J. Physiol. 1995. V. 89. № 1. P. 11–22.