Pilot study of the DRD3, GHRL, FTO, LEPR, INSIG2, GSTP1, ABCB1 genes expression in peripheral blood leukocytes in schizophrenic patients with metabolic syndrome

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Abstract

Many individuals with schizophrenia also suffer from metabolic syndrome (MetS), which is a major risk factor for the development of cardiovascular diseases associated with a heavy burden of disease, as well as with premature death of patients. This study investigated the expression of 7 genes potentially important for the development of metabolic syndrome. QuantiGene Plex 2.0 technology was used to measure how 7 studied genes (DRD3, GHRL, FTO, LEPR, INSIG2, GSTP1, ABCB1 (MDR1)) were expressed by leukocytes in 60 recently admitted patients with schizophrenia who had been on treatment with antipsychotic drugs. The preliminary results of our study show a change in the expression of the FTO gene in schizophrenia male with metabolic disorders, however, further studies are needed to determine the role of disturbances in the expression of this gene in the development of the metabolic syndrome in patients with schizophrenia.

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About the authors

A. S. Boiko

Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences

Email: ivanovaniipz@gmail.com
Russian Federation, Tomsk

D. Z. Paderina

Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences

Email: ivanovaniipz@gmail.com
Russian Federation, Tomsk

E. V. Mikhalitskaya

Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences

Email: ivanovaniipz@gmail.com
Russian Federation, Tomsk

E. G. Kornetova

Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences; Educational Institution of Higher Education “Siberian State Medical University” of the Ministry of Health of the Russian Federation

Email: ivanovaniipz@gmail.com
Russian Federation, Tomsk; Tomsk

N. A. Bokhan

Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences; National Research Tomsk State University

Email: ivanovaniipz@gmail.com
Russian Federation, Tomsk; Tomsk

S. A. Ivanova

Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences; Educational Institution of Higher Education “Siberian State Medical University” of the Ministry of Health of the Russian Federation

Author for correspondence.
Email: ivanovaniipz@gmail.com
Russian Federation, Tomsk; Tomsk

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