The Versatility of Natural Excipient Zein Utilized in Nanocarriers for Improving Biopharmaceutical Attributes


Cite item

Full Text

About the authors

Animesh Ranjan

Department of Regulatory Affairs, ISF College of Pharmacy

Email: info@benthamscience.net

Dilpreet Singh

Department of Regulatory Affairs, ISF College of Pharmacy

Author for correspondence.
Email: info@benthamscience.net

References

  1. Tran PHL, Duan W, Lee BJ, Tran TTD. The use of zein in the controlled release of poorly water-soluble drugs. Int J Pharm 2019; 566: 557-64. doi: 10.1016/j.ijpharm.2019.06.018 PMID: 31181306
  2. Hao L, Lin G, Chen C, Zhou H, Chen H, Zhou X. Phosphorylated zein as biodegradable and aqueous nanocarriers for pesticides with sustained-release and anti-UV properties. J Agric Food Chem 2019; 67(36): 9989-99. doi: 10.1021/acs.jafc.9b03060 PMID: 31430135
  3. Elzoghby A, Freag M, Mamdouh H, Elkhodairy K. Zein-based nanocarriers as potential natural alternatives for drug and gene delivery: Focus on cancer therapy. Curr Pharm Des 2017; 23(35): 5261-71. PMID: 28641543
  4. Alqahtani MS, Islam MS, Podaralla S, et al. Food protein based core–shell nanocarriers for oral drug delivery: Effect of shell composition on in vitro and in vivo functional performance of zein nanocarriers. Mol Pharm 2017; 14(3): 757-69. doi: 10.1021/acs.molpharmaceut.6b01017 PMID: 28103046
  5. Weissmueller NT, Lu HD, Hurley A, Prud’homme RK. Nanocarriers from GRAS zein proteins to encapsulate hydrophobic actives. Biomacromolecules 2016; 17(11): 3828-37. doi: 10.1021/acs.biomac.6b01440 PMID: 27744703
  6. Raza A, Hayat U, Bilal M, Iqbal HMN, Wang JY. Zein-based micro- and nano-constructs and biologically therapeutic cues with multi-functionalities for oral drug delivery systems. J Drug Deliv Sci Technol 2020; 58: 101818. doi: 10.1016/j.jddst.2020.101818
  7. Wang Y, Padua GW. Nanoscale characterization of zein self-assembly. Langmuir 2012; 28(5): 2429-35. doi: 10.1021/la204204j PMID: 22224954
  8. Dahiya S, Rani R, Dhingra D, Kumar S, Dilbaghi N. Conjugation of epigallocatechin gallate and piperine into a zein nanocarrier: Implication on antioxidant and anticancer potential. Adv Nat Sci: Nanosci Nanotechnol 2018; 9(3): 035011. doi: 10.1088/2043-6254/aad5c1
  9. Chen L, Zhou H, Hao L, et al. Dialdehyde carboxymethyl cellulose-zein conjugate as water-based nanocarrier for improving the efficacy of pesticides. Ind Crops Prod 2020; 150: 112358. doi: 10.1016/j.indcrop.2020.112358
  10. Villarreal GPU, Santo Pereira AE, Matos de Freitas RR, et al. Zein-based nanoformulations with encapsulated methyl salicylate incorporated in 3D printing biopolymer devices targeting potential uses in pest management. Colloids Surf A Physicochem Eng Asp 2023; 670: 131511. doi: 10.1016/j.colsurfa.2023.131511
  11. Hao L, Lin G, Wang H, et al. Preparation and characterization of zein-based nanoparticles via ring-opening reaction and self-assembly as aqueous nanocarriers for pesticides. J Agric Food Chem 2020; 68(36): 9624-35. doi: 10.1021/acs.jafc.0c01592 PMID: 32809821
  12. Luo Y, Wang Q. Zein-based micro- and nano-particles for drug and nutrient delivery: A review. J Appl Polym Sci 2014; 131(16) doi: 10.1002/app.40696
  13. Smruthi MR, Nallamuthu I, Anand T. A comparative study of optimized naringenin nanoformulations using nano-carriers (PLA/PVA and zein/pectin) for improvement of bioavailability. Food Chem 2022; 369: 130950. doi: 10.1016/j.foodchem.2021.130950 PMID: 34474288
  14. Gagliardi A, Ambrosio N, Voci S, Salvatici MC, Fresta M, Cosco D. Easy preparation, characterization and cytotoxic investigation of 5-Fluorouracil-loaded zein/sericin nanoblends. J Mol Liq 2022; 366: 120344. doi: 10.1016/j.molliq.2022.120344
  15. Chen Y, Liu C, Yang Z, Sun Y, Chen X, Liu L. Fabrication of zein-based hydrophilic nanoparticles for efficient gene delivery by layer-by-layer assembly. Int J Biol Macromol 2022; 217: 381-97. doi: 10.1016/j.ijbiomac.2022.07.042 PMID: 35839955

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2024 Bentham Science Publishers