A Review on Nanostructured Lipid Carriers as Promising Drug Delivery Vehicle to Target Various Cancers via Oral Route: A Step towards "Chemotherapy at Home"


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Abstract

Oral drug administration is largely preferred owing to enhanced patient compliance, convenience of self-intake of dose, non-invasiveness, and low manufacturing cost. Cancer is a condition that starts with aberrant cell division at an uncontrolled rate. The clinical effectiveness of many anticancer drugs is limited by their physicochemical characteristics and physiological circumstances in the GI tract. Nanostructured lipid carriers have the potential to enhance the bio-availability of anticancer drugs by entrapping them. The NLCs, by virtue of their nanosize and their biocompatibility, can bypass the first-pass metabolism and be taken up by M cells of Peyer’s patches to deliver the drug to the deeper tumours. The proposed review highlights the potential of NLCs in oral drug delivery for the management of various cancers. It discusses various strategies, method of preparation, mechanism of uptake, and their applications in the treatment of cancer via oral delivery. Further, it explains the recent advances and future perspectives.

About the authors

Sheikh Shahnawaz Quadir

Department of Pharmaceutical Sciences, Mohanlal Sukhadia University

Email: info@benthamscience.net

Garima Joshi

Department of Pharmaceutical Sciences, Mohanlal Sukhadia University

Author for correspondence.
Email: info@benthamscience.net

Vinod Saharan

Department of Molecular Biology & Biotechnology, Maharana Pratap University of Agriculture and Technology

Email: info@benthamscience.net

Harish Mangesh

Department of Botany, Mohanlal Sukhadia University

Email: info@benthamscience.net

Deepak Choudhary

Department of Pharmaceutical Sciences, Mohanlal Sukhadia University

Email: info@benthamscience.net

Khushwant Yadav

Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM’s NMIMS (Deemed to be University),

Email: info@benthamscience.net

Chandra Jain

Department of Pharmaceutical Sciences, Mohanlal Sukhadia University

Email: info@benthamscience.net

Lalit Singh Chauhan

Department of Pharmaceutical Sciences, Mohanlal Sukhadia University

Email: info@benthamscience.net

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