Synthesis and Antioxidant Activity of Alkyl N-(9H-Thioxanthen-9-yl)(cyclo)alkylhydrazides

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A series of new alkyl N-(9H-thioxanthen-9-yl)(cyclo)alkylhydrazides was obtained for the first time by the reaction of (cyclo)alkylhydrazides, 9H-thioxanthen-9-ol and pyridinium perchlorate in a pyridine medium. The antioxidant activity of alkyl N-(9H-thioxanthen-9-yl)(cyclo)alkylhydrazides was studied. The greatest antioxidant effect was revealed in linear and cyclic N-(9H-thioxanthen-9-yl)(cyclo)alkylhydrazides, the values of which are in the range of 0.72–0.88 from ascorbic acid. The presence of a branched radical in N-(9H-thioxanthen-9-yl)alkylhydrazides significantly reduces the antioxidant properties.

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作者简介

V. Gorokhov

Institute of Technical Chemistry of the Ural Branch of the Russian Academy of Sciences, Perm Federal Research Center of the Ural Branch of the Russian Academy of Sciences

编辑信件的主要联系方式.
Email: Gorokhov_V.Yu@mail.ru
ORCID iD: 0000-0003-3829-5038
俄罗斯联邦, Perm, 614013

S. Zabolotnykh

Institute of Technical Chemistry of the Ural Branch of the Russian Academy of Sciences, Perm Federal Research Center of the Ural Branch of the Russian Academy of Sciences

Email: Gorokhov_V.Yu@mail.ru
ORCID iD: 0000-0001-8307-0386
俄罗斯联邦, Perm, 614013

A. Kharitonova

Institute of Technical Chemistry of the Ural Branch of the Russian Academy of Sciences, Perm Federal Research Center of the Ural Branch of the Russian Academy of Sciences

Email: Gorokhov_V.Yu@mail.ru
ORCID iD: 0000-0002-4791-5799
俄罗斯联邦, Perm, 614013

L. Chekanova

Institute of Technical Chemistry of the Ural Branch of the Russian Academy of Sciences, Perm Federal Research Center of the Ural Branch of the Russian Academy of Sciences

Email: Gorokhov_V.Yu@mail.ru
ORCID iD: 0000-0003-1792-6945
俄罗斯联邦, Perm, 614013

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2. Fig. 1. General view of the 4d compound molecule according to X-ray diffraction data, represented by thermal ellipsoids with a 30% probability.

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3. 2. Values of antioxidant activity of alkyl-N-(9H-thioxanthene-9-yl)(cyclo)alkylhydrazides 4a–K.

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4. 3. Spectra of the FRAP solution before and after the addition of ascorbic acid (AC) or compound 4j (l = 10 mm, background – water, CA = 2.5·10-3 mol/l, c4j = 10-3 mol/l).

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5. Scheme 1.

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