Volume 94, Nº 6 (2024)

This review analyzes publications that present the results of studies of modern and traditional approaches to the synthesis of 2,2-dimethyl-4-hydroxymethyl-1,3-dioxolane, as well as data on methods for its use in organic synthesis. The ways of obtaining enantiomerically pure 2,2-dimethyl-4-hydroxymethyl-1,3-dioxolanes, necessary in the production of drugs, are shown. Publications devoted to the use of 2,2-dimethyl-4-hydroxymethyl-1,3-dioxolane in pharmaceutical, medicinal chemistry and petrochemistry are presented.

Ethyl 4-aryl-2-oxo-2,3,4,10-tetrahydrobenzo[4,5]imidazo[1,2-a]pyrimidine-3-carboxylates were prepared by three-component one-pot condensation of diethylmalonate, aromatic aldehyde, 2-aminobenzimidazole in ethanol in the presence of piperidine. The structure of the obtained compounds was determined by ¹H, ¹³С NMR spectroscopy and single crystal X-ray diffraction analysis.

New derivatives of the quinolizidine alkaloid, (–)-cytisine, with a substituted 2-pyridone ring and a thiourea moiety in the bispidin fragment of the molecule were synthesized. The ability of the synthesized cytisine-containing thioureas to inhibit the reproduction of human parainfluenza virus type 3 was assessed. It was found that the derivatives obtained by the reaction of benzoyl or phenyl isothiocyanate with (–)-cytisine, as well as its 9-bromo or 9,11-derivative, effectively suppress the reproduction of human parainfluenza virus type 3 (their selectivity indices are 56, 58 and 95, respectively), which confirms the promise of the chosen approach to synthetic modifications of the alkaloid (–)-cytisine in order to obtain effective antiviral agents on its basis.

The effect of aminophenol, amino acids and their derivatives on the level of ^•NO and its intermediates (^•NO₂, N₂O₃) in an aqueous aerobic media (pH = 7.4) was studied using nitroprusside as a ^•NO donor. It was found that the highest NO_x scavenging activity is exhibited by 3-aminophenol (IC₅₀ = 0.11 mM), 2-aminophenol (IC₅₀ = 0.195 mM) and 4,6-di-tert-butyl-2-aminophenol (IC₅₀ = 0.12 mM), standards: trolox (IC₅₀ = 0.19 mM) and ascorbate (IC₅₀ = 4.88 mM). Methylation of the OH group reduced the effectiveness of aminophenol. In the studied concentration range (0–70 mM), Tyr-Ala (IC₅₀ = 5.0 mM) and β-Ala-His (IC₅₀ = 35.0 mM) were more active than Phe-Ala (IC₅₀ > 50 mM) and Gly-Gly (IC₅₀ > 50 mM). Complexes Cu(Gly)₂ and Cu(Gly-Gly)₂ at low concentrations (0.05–0.5 mM) are 1.4–1.8 times more effective than Gly and Gly-Gly.

The system Fe(II)–Fe(III)–Co(II)–Gly–H₂O was studied by the Clark–Nikolsky oxidation potential method at a temperature of 298.15 K, ionic strength of the solution [Na(H)CIO₄] I = 1.0 mol/l. The formation of mononuclear and heteronuclear compounds of various compositions in the system was found: [FeHL(H₂O)₅]³⁺, [Fe(HL)₂(H₂O)₄]³⁺, [Fe(HL)(OH)(H₂O)₄]²⁺, [СoL(H₂O)₅]⁺, [Fe^IIIСo^IIL(H₂O)₁₁]⁴⁺, [Fe^IIIСo^II(L)₂(H₂O)₁₀]³⁺, [FeL(H₂O)₅]⁺, [Fe(HL)₂(H₂O)₄]²⁺, [Fe(HL)(OH)(H₂O)₄]⁺ and [Fe(HL)(OH)₂(H₂O)₃]⁰. The stability and model parameters of coordination compounds were calculated by the Yusupov oxidation function iteration method, and their coordination compound distribution diagrams were constructed. It was found that the heteronuclear complex [Fe^IIIСo^IIL(H₂O)₁₁]⁴⁺ is the most stable, with an accumulation degree of 99.50%, and exists up to pH = 9.5.

Eu(III) compounds with pyrazine-2-carboxylic acid and nitrogen- and phosphorus-containing neutral ligands were synthesized. Using the methods of chemical elemental and thermal analysis and IR spectroscopy, the composition of the complexes and the method of coordination of carboxylate ions were established. The most thermally stable compounds have been identified. The luminescent characteristics of complex compounds have been studied. It was found that the maximum luminescence intensity is characteristic of europium(III) pyrazinate with triphenylphosphine oxide. The morphological structure and dispersion of the complexes were determined.