A new method for the synthesis of 2,3-aryl-5-arylideneimidazol-4-ones using N-trimethylsilylimidazole

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Resumo

A new method was developed for the synthesis of 5-arylidene-2,3-disubstituted 4 H -imidazol-4-ones by cyclization of N -substituted α,β-dehydroamino acid arylamides with N -trimethylsilylimidazole (TMSIM) in dimethylformamide. The process was carried out by both conventional and microwave heating. Target imidazol-4-one was also synthesized by a one-pot method based on the reaction of unsaturated 5(4 H )-oxazolone, arylamine, and TMSIM. The anticholinesterase and antiradical properties of synthesized both arylamides and 4-imidazolones were studied.

Sobre autores

V. Topuzyan

Scientific Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

S. Tosunyan

Scientific Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

E. Aleksanyan

Scientific Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

E. Hakobyan

Scientific Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

N. Hovhannisyan

Scientific Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

A. Makichyan

Scientific Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

Email: ani.makichyan@rau.am

A. Shahkhatuni

Scientific Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

A. Hovhannisyan

Scientific Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

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