Fe(III), Co(III), and Cu(II) Complexes with Acylhydrazones Containing a Triphenylphosphonium Moiety: Synthesis, Crystal Structure, and Antibacterial Activity

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Abstract

New acylhydrazones based on para- and meta-nitrobenzhydrazides and substituted salicylic aldehyde containing a triphenylphosphonium fragment were synthesized and spectrally characterized. With these acylhydrazones, a series of new mononuclear coordination compounds of Fe(III), Co(III), and Cu(II) were obtained, the molecular structure of which was determined by single-crystal X-ray diffraction. The antibacterial activity of the isolated acylhydrazones and copper(II) complexes against Staphylococcus aureus and Escherichia coli was studied. It was shown that the transition from an organic compound to a complex one contributes to a significant increase in activity against E. coli.

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About the authors

A. K. Matiukhina

Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences

Email: ezorinatikhonova@igic.ras.ru
Russian Federation, Moscow

E. N. Zorina-Tikhonova

Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences

Author for correspondence.
Email: ezorinatikhonova@igic.ras.ru
Russian Federation, Moscow

N. V. Gogoleva

Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences

Email: ezorinatikhonova@igic.ras.ru
Russian Federation, Moscow

L. D. Popov

Southern Federal University

Email: ezorinatikhonova@igic.ras.ru
Russian Federation, Rostov-on-Don

P. G. Morozov

Southern Federal University

Email: ezorinatikhonova@igic.ras.ru
Russian Federation, Rostov-on-Don

V. A. Lazarenko

National Research Center “Kurchatov Institute”

Email: ezorinatikhonova@igic.ras.ru
Russian Federation, Moscow

A. A. Zubenko

North Caucasus Zonal Research Veterinary Institute, Branch, Federal Rostov Agrarian Research Center

Email: ezorinatikhonova@igic.ras.ru
Russian Federation, Novocherkassk

L. N. Fetisov

North Caucasus Zonal Research Veterinary Institute, Branch, Federal Rostov Agrarian Research Center

Email: ezorinatikhonova@igic.ras.ru
Russian Federation, Novocherkassk

A. E. Svyatogorova

North Caucasus Zonal Research Veterinary Institute, Branch, Federal Rostov Agrarian Research Center

Email: ezorinatikhonova@igic.ras.ru
Russian Federation, Novocherkassk

M. A. Kiskin

Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences

Email: ezorinatikhonova@igic.ras.ru
Russian Federation, Moscow

I. L. Eremenko

Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences

Email: ezorinatikhonova@igic.ras.ru
Russian Federation, Moscow

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Supplementary files

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1. JATS XML
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2. Scheme 1. General scheme for the synthesis of acylhydrazones (H₂L¹)Cl, (H₂L²)Cl and complexes I–VI.

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3. Fig. 1. Structure of complexes II (a) and III (b) (hydrogen atoms are not shown).

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4. Fig. 2. Structure of complexes V (a) and VI (b) (nitrate anions, hydrogen atoms and solvate molecules are not shown).

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5. Additional materials
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